A UNIQUE METABOLISM OF INORGANIC ARSENIC IN NATIVE ANDEAN WOMEN
A UNIQUE METABOLISM OF INORGANIC ARSENIC IN NATIVE ANDEAN WOMEN
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DOI：
10.1016/s0014-2999(95)80104-9
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发表时间：
1995-12-07
期刊：
影响因子：
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通讯作者：
NATARAJAN, AT
中科院分区：
文献类型：
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作者：
VAHTER, M;CONCHA, G;NATARAJAN, AT
无机砷（As）在阿根廷西北部的安第斯山脉的四个村庄的土著妇女的代谢水平升高的饮用水（2.5，14，31，和200微克/升，分别）进行了调查。收集的食物中含有9-427微克砷/公斤湿重，汤中浓度最高。血液中的总砷浓度显着升高（中位数7.6微克/升），只有在饮用水中浓度最高的村庄。尿中无机砷代谢物（无机砷、甲基胂酸（MMA）和二甲基胂酸（DMA））的组中位浓度在14和256微克/升之间变化。尿中总砷浓度仅略高（18-258微克/升），表明无机砷是摄入的砷的主要形式。与迄今为止研究的所有其他人群相比，砷主要以无机As和DMA的形式在尿液中排泄。尿中MMA含量非常少（总体中位数为2.2%，范围为0.0-11%），应与所有其他研究人群中尿砷含量的10-20%进行比较。这可能表明在控制参与As甲基化的甲基转移酶活性方面存在遗传多态性。此外，DMA在尿液中的百分比显着较高的村庄与200亩砷/升的水，表明诱导形成的DMA。在其他对砷暴露量增加的人类受试者进行的研究中没有观察到这种影响。
The metabolism of inorganic arsenic (As) in native women in four Andean villages in north-western Argentina with elevated levels of As in the drinking water (2.5, 14, 31, and 200 mu g/l, respectively) has been investigated. Collected foods contained 9-427 mu g As/kg wet weight, with the highest concentrations in soup. Total As concentrations in blood were markedly elevated (median 7.6 mu g/l) only in the village with the highest concentration in the drinking water. Group median concentrations of metabolites of inorganic As (inorganic As, methylarsonic acid (MMA) and dimethylarsinic acid (DMA)) in the urine varied between 14 and 256 mu g/l. Urinary concentrations of total As were only slightly higher (18-258 mu g/l), indicating that inorganic As was the main form of As ingested. In contrast to all other populations studied so far, arsenic was excreted in the urine mainly as inorganic As and DMA. There was very little MMA in the urine (overall median 2.2%, range 0.0-11%), which should be compared to 10-20% of the urinary arsenic in all other populations studied. This may indicate the existence of genetic polymorphism in the control of the methyltransferase activity involved in the methylation of As. Furthermore, the percentage of DMA in the urine was significantly higher in the village with 200 mu g As/l in the water, indicating an induction of the formation of DMA. Such an effect has not been observed in other studies on human subjects with elevated exposure to arsenic.