Virological features and clinical manifestations associated with human metapneumovirus:: A new paramyxovirus responsible for acute respiratory-tract infections in all age groups
Virological features and clinical manifestations associated with human metapneumovirus:: A new paramyxovirus responsible for acute respiratory-tract infections in all age groups
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DOI：
10.1086/344319
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发表时间：
2002-11-01
影响因子：
6.4
通讯作者：
Anderson, LJ
中科院分区：
文献类型：
--
作者：
Boivin, G;Abed, Y;Anderson, LJ
回顾性分析了1993年以来加拿大因各种呼吸系统疾病住院的患者中与新型人偏肺病毒（HMPV）相关的病毒学特征和临床表现。通过逆转录聚合酶链反应，从恒河猴种类（LLC-MK2）细胞中分离到38株HMPV阳性的呼吸道病毒，这些病毒聚集在2个系统发育群中。年龄< 0岁的儿童和年龄165岁的老年人分别占hmpv感染病例的35.1%和45.9%。在住院儿童中，最常见的诊断是肺炎（66.7%）和细支气管炎（58.3%），而支气管炎和/或支气管痉挛（60%）和肺炎（40%）在老年人中最常见。在15例肺炎患者中，4例（26.7%）存在免疫抑制，6例（40%）为婴幼儿
The virological features and clinical findings associated with the new human metapneumovirus (HMPV) were examined retrospectively in Canadian patients hospitalized for various respiratory conditions since 1993. Thirty-eight previously unidentified respiratory viruses isolated from rhesus monkey kindey (LLC-MK2) cells were found to be positive for HMPV by reverse-transcription polymerase chain reaction, and those strains clustered in 2 phylogenetic groups. Children aged < years and elderly subjects aged 1 65 years represented 35.1% and 45.9% of the HMPV-infected cases, respectively. In hospitalized children, the most frequent diagnoses were pneumonitis (66.7%) and bronchiolitis (58.3%), whereas bronchitis and/or bronchospasm (60%) and pneumonitis (40%) were most commonly seen in elderly subjects. Of the 15 patients with pneumonitis, 4 (26.7%) had immunosuppressive conditions and 6 (40%) were infants aged