Effect of experimental analogs of contingency management treatment on cocaine seeking behavior
Effect of experimental analogs of contingency management treatment on cocaine seeking behavior
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DOI：
10.1016/j.drugalcdep.2014.03.009
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发表时间：
2014-06-01
影响因子：
4.2
通讯作者：
Steinmiller, Caren L.
中科院分区：
文献类型：
--
作者：
Greenwald, Mark K.;Ledgerwood, David M.;Steinmiller, Caren L.
背景资料：应急管理（CM）治疗是有效的治疗可卡因依赖，但其疗效的进一步机制的研究是必要的。这项研究旨在确定：（a）较高与较低的可预测资金数额（3美元对1美元;基于凭证的标准CM的类似物）增加可卡因需求弹性;以及（B）与3美元可预测量匹配的预期值的概率量（$6的机会为50%;$12的机会为25%;$24的机会为12.5%;奖品CM的类似物）同样影响可卡因的选择。15名可卡因依赖的参与者中的每一个首先完成一个资格会议，以确保鼻内可卡因作为一种兴奋剂，然后完成10个会议，在受试者，随机交叉研究。在每一个10届会议期间，参与者响应的累进比例时间表，以赚取单位的可卡因（5毫克或10毫克）和/或金钱（五个以上的货币条件）。结果：在强化资格会议（10毫克与0毫克单位;没有钱的替代品），可卡因的选择是高的。相对于1美元可预测量和资格赛，3美元可预测量显著降低了可卡因选择。可卡因的概率条件的选择是类似的$3 predictable condition.Conclusions：这些研究结果表明，CM干预措施，针对减少可卡因自我管理更有可能成功与更高的价值非药物加固。(C)由Elsevier爱尔兰Ltd.出版
Background: Contingency management (CM) treatment is effective for treating cocaine dependence but further mechanistic studies of its efficacy are warranted. This study aimed to determine whether: (a) higher vs. lower predictable money amounts ($3 vs. $1; analogs of standard voucher-based CM) increase cocaine demand elasticity; and (b) probabilistic amounts matched for expected value with the $3-predictable amount (50% chance of $6; 25% chance of $12; and 12.5% chance of $24; analogs of prize CM) similarly affect cocaine choice.Methods: Each of 15 cocaine-dependent participants first completed a qualifying session to ensure that intranasal cocaine functioned as a reinforcer, then completed a 10-session, within-subject, randomized crossover study. During each of the 10 sessions, the participant responded on a progressive ratio schedule to earn units of cocaine (5-mg or 10-mg) and/or money (five monetary conditions above).Results: During the reinforcement qualifying session (10-mg vs. 0-mg units; no money alternative), cocaine choice was high. The $3-predictable amount significantly decreased cocaine choice relative to both the $1-predictable amount and the qualifying session. Cocaine-choices in the probabilistic conditions were similar to the $3 predictable condition.Conclusions: These findings indicate that CM interventions targeted at reducing cocaine self-administration are more likely to succeed with higher value non-drug reinforcement. (C) 2014 Published by Elsevier Ireland Ltd.