Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: Treatment with simvastatin
Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: Treatment with simvastatin
复制标题
DOI：
10.1001/archinte.163.15.1837
复制
发表时间：
2003-08-11
影响因子：
--
通讯作者：
Kastelein, JJP
中科院分区：
文献类型：
--
作者：
Nolting, PRWD;de Groot, E;Kastelein, JJP
目的：为了探讨是否高剂量辛伐他汀治疗可以降低家族性高胆固醇血症（FH）患者的颈动脉和股动脉内膜中层厚度（IMT），以防止心血管疾病。背景：动脉壁成像与B超越来越多地被用作心血管疾病的非侵入性替代标记。使用这种方式的干预试验表明，通过减少危险因素，动脉粥样硬化的进展被inhibit.Methods：经过6周的洗脱期，所有FH患者开始单药治疗与辛伐他汀，80 mg/d，2年。主要终点是平均组合远壁IMT的预定义的颈动脉和股动脉段在2 years.Results的变化（毫米）：我们共纳入153例FH患者。平均+/- SD合并基线IMT为1.07 +/- 0.23 mm。经辛伐他汀治疗2年后，IMT平均下降0.081 mm（95%置信区间，-0.109至-0.053; P
Objective: To investigate whether high-dose simvastatin therapy could reduce carotid and femoral artery intima-media thickness (IMT) in patients with familial hypercholesterolemia (FH) to prevent cardiovascular disease.Background: Imaging of arterial walls with B-mode ultrasonography is increasingly used as a noninvasive surrogate marker of cardiovascular disease. Intervention trials using this modality have shown that by reducing risk factors, progression of atherosclerosis was inhibited.Methods: After a washout period of 6 weeks, all patients with FH started monotherapy with sinivastatin, 80 mg/d, for 2 years. The primary end point was the change (in millimeters) of the mean combined far-wall IMT of predefined carotid and femoral arterial segments at 2 years.Results: We included a total of 153 patients with FH. Mean +/- SD combined baseline IMT was 1.07 +/- 0.23 mm. After treatment with sinivastatin for 2 years, this IMT decreased by a mean of 0.081 mm (95% confidence interval, -0.109 to -0.053; P