The relationship of blood lead to blood pressure in a longitudinal study of working men.
The relationship of blood lead to blood pressure in a longitudinal study of working men.
复制标题
对职业男性的纵向研究显示血液与血压的关系。
DOI：
10.1093/oxfordjournals.aje.a114309
复制
发表时间：
1986
影响因子：
5
通讯作者：
Speizer,FE
中科院分区：
文献类型：
--
作者：
Weiss,ST;Muñoz,A;Stein,A;Sparrow,D;Speizer,FE
在对马萨诸塞州波士顿市89名警察进行的一项纵向研究中，对铅暴露与血压的关系进行了研究。在基线检查时，受试者进行血铅测定和连续三次血压测量。还在第3、4和5年进行了三次血压测量。多变量分析显示，在校正先前的收缩压、体重指数、年龄和吸烟后，高水平的血铅是随后收缩压升高的重要预测因素。这些模型的Bootstrap模拟为观察到的关联提供了支持证据。这些数据表明，铅暴露可以显着影响收缩压。
The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.