Transglutaminase is a tumor cell and cancer stem cell survival factor.
Transglutaminase is a tumor cell and cancer stem cell survival factor.
复制标题
DOI：
10.1002/mc.22375
复制
发表时间：
2015-10
影响因子：
4.6
通讯作者：
Kerr C
中科院分区：
文献类型：
--
作者：
Eckert RL;Fisher ML;Grun D;Adhikary G;Xu W;Kerr C
最近的研究表明，癌细胞表达升高水平的II型转氨酶（TG 2），并且该表达在源自这些癌症的癌症干细胞中进一步高度富集。此外，升高的TG 2表达与增强的癌症干细胞标志物表达、存活信号传导、增殖、迁移、侵袭、整合素介导的粘附、上皮-间充质转化和耐药性相关。TG 2表达还与对常规治疗干预具有抗性的侵袭性和转移性肿瘤的形成相关。本文综述了TG 2作为一种癌细胞存活因子在一系列肿瘤类型中的作用，以及作为预防和治疗干预的靶点。文献支持这样的观点，即处于闭合/GTP结合/信号传导构象的TG 2驱动癌细胞和癌症干细胞存活，并且处于开放/交联构象的TG 2与细胞死亡相关。
Recent studies indicate that cancer cells express elevated levels of type II transglutaminase (TG2), and that expression is further highly enriched in cancer stem cells derived from these cancers. Moreover, elevated TG2 expression is associated with enhanced cancer stem cell marker expression, survival signaling, proliferation, migration, invasion, integrin-mediated adhesion, epithelial–mesenchymal transition, and drug resistance. TG2 expression is also associated with formation of aggressive and metastatic tumors that are resistant to conventional therapeutic intervention. This review summarizes the role of TG2 as a cancer cell survival factor in a range of tumor types, and as a target for preventive and therapeutic intervention. The literature supports the idea that TG2, in the closed/GTP-binding/signaling conformation, drives cancer cell and cancer stem cell survival, and that TG2, in the open/crosslinking conformation, is associated with cell death.