Dopamine and cognitive control:: The influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility
Dopamine and cognitive control:: The influence of spontaneous eyeblink rate and dopamine gene polymorphisms on perseveration and distractibility
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DOI：
10.1037/0735-7044.119.2.483
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发表时间：
2005-04-01
影响因子：
1.9
通讯作者：
Brocke, B
中科院分区：
文献类型：
--
作者：
Dreisbach, G;Müller, J;Brocke, B
追求目标导向行为的智能生物体的一个基本问题是如何动态调节维持性和灵活性之间的平衡。作者表明，自发眨眼率和多巴胺基因多态性表明，中枢多巴胺能活性在这种平衡的调节中发挥着重要作用。七十二名年轻人接受了检查。与眨眼率低的参与者相比，眨眼率高的参与者表现出更高的认知灵活性，但认知稳定性降低。这种结果模式对于 DRD4 外显子 III 4/7 基因型的携带者来说更为明显，尽管没有发现 DRD4 和 COMT 多态性的主要影响。结果与神经心理学模型一致，表明前额叶多巴胺能活动对认知控制过程具有调节作用。
One fundamental problem of intelligent organisms pursuing goal-directed behavior is how to dynamically regulate the balance between maintenance and flexibility. The authors show that central dopaminergic activity, as indicated by spontaneous eyeblink rate and dopamine gene polymorphisms, plays an important role in the modulation of this balance. Seventy-two young adults were examined. Participants with high blink rates showed increased cognitive flexibility but decreased cognitive stability compared with participants with low blink rates. This pattern of results was even more pronounced for carriers of the DRD4 exon III 4/7 genotype, even though no main effects were found for DRD4 and COMT polymorphisms. Results converge with neuropsychological models that suggest a modulatory role of prefrontal dopaminergic activity for processes of cognitive control.