A Dual Role of Type I Interferons in Antitumor Immunity
A Dual Role of Type I Interferons in Antitumor Immunity
复制标题
I 型干扰素在抗肿瘤免疫中的双重作用。
DOI：
10.1002/adbi.201900237
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发表时间：
2020
影响因子：
4.1
通讯作者：
Fangfang Zhou
中科院分区：
文献类型：
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作者：
Lili Zhou;Yuqi Zhang;Yongqiang Wang;Meirong Zhang;Wenhuan Sun;Tong Dai;Aijun Wang;Xiaojin Wu;Suping Zhang;Shuai Wang;Fangfang Zhou
I型干扰素是一类细胞因子家族，通过直接和间接机制发挥直接的抗病毒作用，调节先天和获得性免疫反应。一般认为，干扰素通过抑制肿瘤增殖和诱导抗肿瘤免疫反应来抑制肿瘤的发展。然而，最近新出现的证据表明，干扰素-1在抗肿瘤免疫中具有双重作用。也就是说，在肿瘤发生的早期，干扰素-1通过增强抗原提呈细胞的抗原提呈和激活CD8+T细胞来促进抗肿瘤免疫反应。然而，在肿瘤进展的晚期，干扰素-IS的持续表达会诱导树突状细胞和其他骨髓细胞表面免疫抑制因子(PD-L1、IDO和IL-10)的表达，从而抑制其抗肿瘤免疫。本文概述了干扰素-1在抗肿瘤免疫中的双重作用，阐明了其作用机制，并对其在肿瘤治疗中的应用进行了综述。
Type I interferons (IFN‐Is) are a family of cytokines that exert direct antiviral effects and regulate innate and adaptive immune responses through direct and indirect mechanisms. It is generally believed that IFN‐Is repress tumor development via restricting tumor proliferation and inducing antitumor immune responses. However, recent emerging evidence suggests that IFN‐Is play a dual role in antitumor immunity. That is, in the early stage of tumorigenesis, IFN‐Is promote the antitumor immune response by enhancing antigen presentation in antigen‐presenting cells and activating CD8+T cells. However, in the late stage of tumor progression, persistent expression of IFN‐Is induces the expression of immunosuppressive factors (PD‐L1, IDO, and IL‐10) on the surface of dendritic cells and other bone marrow cells and inhibits their antitumor immunity. This review outlines these dual functions of IFN‐Is in antitumor immunity and elucidates the involved mechanisms, as well as their applications in tumor therapy.