Antiviral drugs: current state of the art
Antiviral drugs: current state of the art
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DOI：
10.1016/s1386-6532(01)00167-6
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发表时间：
2001-08-01
影响因子：
8.8
通讯作者：
De Clercq, E
中科院分区：
文献类型：
--
作者：
De Clercq, E
病毒感染的化疗无疑已经成熟。目前有 15 种抗病毒药物已正式获得许可用于治疗人类免疫缺陷病毒感染（齐多夫定、去羟肌苷、扎西他滨、司他夫定、拉米夫定、阿巴卡韦、奈韦拉平、地拉夫定、依非韦伦、沙奎那韦、利托那韦、茚地那韦、奈非那韦、安普那韦、洛匹那韦）以及其他几种药物，例如替诺福韦disoproxil、emtricitabine、capravirine、emivirine、T-20（pentafuside）和 AMD3100（bicyclam）正在临床开发中。拉米夫定已获得批准，其他几种化合物（如阿德福韦酯、恩曲他滨和恩替卡韦）正在临床开发中，用于治疗乙型肝炎病毒感染。在抗疱疹病毒药物中，阿昔洛韦、伐昔洛韦、喷昔洛韦、泛昔洛韦、碘尿苷、三氟尿苷和布夫定用于治疗单纯疱疹病毒和水痘带状疱疹病毒感染，更昔洛韦、膦甲酸、西多福韦、福米韦森和马瑞巴韦（后者处于发育阶段）用于治疗巨细胞病毒感染。继金刚烷胺和金刚乙胺之后，神经氨酸酶抑制剂扎那米韦和奥司他韦现已可用于治疗和预防流感病毒感染，利巴韦林也可用于治疗呼吸道合胞病毒感染，利巴韦林与干扰素-cr联合用于治疗丙型肝炎病毒感染。 (C) 2001 Elsevier Science B.V. 保留所有权利。
The chemotherapy of virus infections has definitely come of age. There are now 15 antiviral agents that have been formally licensed for the treatment of human immunodeficiency virus infections (zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir, nevirapine, delavirdine, efavirenz, saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir) and several others, such as tenofovir disoproxil, emtricitabine, capravirine, emivirine, T-20 (pentafuside) and AMD3100 (bicyclam) are under clinical development. Lamivudine has been approved, and several other compounds (such as adefovir dipivoxil, emtricitabine and entecavir) are under clinical development, for the treatment of hepatitis B virus infections. Among the anti-herpesvirus agents, aciclovir, valaciclovir, penciclovir, famciclovir, idoxuridine, trifluridine and brivudin are used in the treatment of herpes simplex virus and varicella-zoster virus infections, and ganciclovir, foscarnet, cidofovir, fomivirsen and maribavir (the latter in the developmental stage) are used in the treatment of cytomegalovirus infections. Following amantadine and rimantadine, the neuraminidase inhibitors, zanamivir and oseltamivir, have now become available for the therapy and prophylaxis of influenza virus infections, and so is ribavirin for the treatment of respiratory syncytial virus infections and the combination of ribavirin with interferon-cr for the treatment of hepatitis C virus infections. (C) 2001 Elsevier Science B.V. All rights reserved.