HISTOLOGICAL OSTEOMALACIA DUE TO DIETARY CALCIUM DEFICIENCY IN CHILDREN
HISTOLOGICAL OSTEOMALACIA DUE TO DIETARY CALCIUM DEFICIENCY IN CHILDREN
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DOI：
10.1056/nejm198209023071003
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
GLORIEUX, FH
中科院分区：
文献类型：
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作者：
MARIE, PJ;PETTIFOR, JM;GLORIEUX, FH
对3例临床表现为缺钙性佝偻病的儿童的髂嵴不脱钙切片进行骨小梁形成和骨吸收的组织形态计量学研究。所有3名儿童都有严重的骨软化症，记录为类骨质增生和骨矿化的静态和动态指标降低。钙化骨体积减少，骨形成率降低，骨吸收增加。2例患者纠正饮食钙摄入导致血清和尿钙水平正常，碱性磷酸酶水平降低。钙治疗后，钙化骨体积正常，骨矿化指标恢复正常。儿童低钙摄入可能与严重骨软化的组织学表现有关。事实上，适量的钙迅速改善骨矿化表明，钙缺乏可导致儿童骨软化症。
A histomorphometric study of trabecular-bone formation and resorption in undecalcified sections of iliac crest from 3 children presenting with clinical radiologic and biochemical evidence of rickets associated with dietary Ca deficiency was performed. All 3 children had severe osteomalacia documented by hyperosteoidosis and reduced static and dynamic indicators of bone mineralization. There was a reduction of the calcified bone volume associated with a decreased bone formation rate and features of increased bone resorption. Correction of dietary Ca intake in 2 of the patients led to normal serum and urinary Ca levels and reduced alkaline phosphatase levels. After Ca therapy, the calcified bone volume was normal and indicators of bone mineralization returned to normal. Low Ca intake in children may be associated with a histologic picture of severe osteomalacia. The fact that adequate amounts of Ca rapidly improved bone mineralization demonstrates that Ca deficiency can cause osteomalacia in children.