The 8q24 gene desert: an oasis of non-coding transcriptional activity.
The 8q24 gene desert: an oasis of non-coding transcriptional activity.
复制标题
8q24 基因沙漠：非编码转录活性的绿洲。
DOI：
10.3389/fgene.2012.00069
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发表时间：
2012
影响因子：
3.7
通讯作者：
Caplen NJ
中科院分区：
文献类型：
--
作者：
Huppi K;Pitt JJ;Wahlberg BM;Caplen NJ
由于基因座的复杂性，了解与癌症中人类染色体8q24区域相关的广泛异常遗传特征的功能影响仍然令人生畏。最符合逻辑的研究目标仍然是MYC原癌基因，它是世纪前首次发现的8q24的主要居民。然而，与8q24相关的许多扩增、易位断点和病毒整合位点通常在包括其他转录物的MYC基因座的大范围周围区域中发现。此外，chr.8q24是许多与癌症风险相关的单核苷酸多态性的宿主。然而，癌症风险等位基因和MYC表达之间缺乏直接相关性也提出了MYC并不总是这些遗传关联的目标的可能性。8q24区域被描述为“基因沙漠”，因为该区域内缺乏功能注释的基因。在这里，我们回顾了8q24区域内的其他位点的作用的证据，其中大部分是非编码转录本，无论是在音乐会与MYC或独立的MYC，作为可能的候选基因靶在恶性肿瘤。
Understanding the functional effects of the wide-range of aberrant genetic characteristics associated with the human chromosome 8q24 region in cancer remains daunting due to the complexity of the locus. The most logical target for study remains the MYC proto-oncogene, a prominent resident of 8q24 that was first identified more than a quarter of a century ago. However, many of the amplifications, translocation breakpoints, and viral integration sites associated with 8q24 are often found throughout regions surrounding large expanses of the MYC locus that include other transcripts. In addition, chr.8q24 is host to a number of single nucleotide polymorphisms associated with cancer risk. Yet, the lack of a direct correlation between cancer risk alleles and MYC expression has also raised the possibility that MYC is not always the target of these genetic associations. The 8q24 region has been described as a “gene desert” because of the paucity of functionally annotated genes located within this region. Here we review the evidence for the role of other loci within the 8q24 region, most of which are non-coding transcripts, either in concert with MYC or independent of MYC, as possible candidate gene targets in malignancy.