Regulation of granulopoiesis following severe thermal injury.
Regulation of granulopoiesis following severe thermal injury.
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严重热损伤后粒细胞生成的调节。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
W. Robinson
中科院分区：
文献类型：
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作者：
V. Peterson;J. Hansbrough;C. Buerk;C. Rundus;S. Wallner;H. Smith;W. Robinson
烧伤病人中性粒细胞增多症常伴有败血症。这一矛盾现象表明粒细胞生成的调节存在缺陷。由单核细胞-巨噬细胞系统产生的集落刺激因子（CSF）是粒细胞产生的重要调节因子。我们对22例烧伤面积大于30%的患者进行了一系列的血清CSF水平和外周血白细胞分类计数。6名患者（平均烧伤，58%）发生革兰氏阴性败血症并死亡（组I）。16名患者（平均烧伤，38%）没有致命的败血症（组II）。非幸存者最初CSF水平较低，并发展为持续性单核细胞减少症。相反，存活者CSF迅速升高并发生单核细胞增多症。组I中存在单核细胞减少症和低CSF水平表明调节粒细胞生成的刺激臂异常。这种缺陷可能在严重热损伤后致命性败血症的发展中发挥作用。
Neutropenia often accompanies septicemia in burned patients. This paradox suggests a defect in the regulation of granulopoiesis. Colony stimulating factor (CSF) produced by the monocyte-macrophage system is an important regulator of granulocyte production. We followed serial serum CSF levels and peripheral blood leukocyte differential counts in 22 patients with greater than 30% burns. Six patients (mean burn, 58%) developed Gram-negative septicemia and died (Group I). Sixteen patients (mean burn, 38%) had no fatal septicemias (Group II). Nonsurvivors had initially low levels of CSF and developed persistent monocytopenia. Survivors, in contrast, had prompt rises in CSF and developed monocytosis. The presence of monocytopenia and low CSF levels in Group I suggests an abnormality in the stimulatory arm regulating granulopoiesis. Such a defect may play a role in the development of fatal septicemia following severe thermal injury.