DeOri: a database of eukaryotic DNA replication origins
DeOri: a database of eukaryotic DNA replication origins
复制标题
DeOri：真核 DNA 复制起点数据库
DOI：
10.1093/bioinformatics/bts151
复制
发表时间：
2012-06-01
期刊：
影响因子：
5.8
通讯作者：
Zhang, Chun-Ting
中科院分区：
文献类型：
--
作者：
Gao, Feng;Luo, Hao;Zhang, Chun-Ting
摘要
DNA复制是细胞增殖的中心事件，是生物遗传的基础。复制起点的识别有助于揭示DNA复制调控的机制。然而，不久前只有很少的真核复制起始点被表征；然而，最近的全基因组方法增加了绘制的复制起始点的数量。为了全面了解真核生物复制起始点的性质，我们构建了一个真核复制起始点数据库(DEORI)，该数据库包含了目前可用全基因组分析鉴定的所有真核复制起始点。从6种已进行全基因组研究的真核生物中收集到16145个真核复制起点，其中人、小鼠、拟南芥、乳酸克鲁维酵母、裂殖酵母和黑腹果蝇的复制起始点数分别为433、7489、1543、148、348和6184个。
可用性
真核生物Oris数据库(DEORI)可从http://tubic.tju.edu.cn/deori/访问
SUMMARY
DNA replication, a central event for cell proliferation, is the basis of biological inheritance. The identification of replication origins helps to reveal the mechanism of the regulation of DNA replication. However, only few eukaryotic replication origins were characterized not long ago; nevertheless, recent genome-wide approaches have boosted the number of mapped replication origins. To gain a comprehensive understanding of the nature of eukaryotic replication origins, we have constructed a Database of Eukaryotic ORIs (DeOri), which contains all the eukaryotic ones identified by genome-wide analyses currently available. A total of 16 145 eukaryotic replication origins have been collected from 6 eukaryotic organisms in which genome-wide studies have been performed, the replication-origin numbers being 433, 7489, 1543, 148, 348 and 6184 for humans, mice, Arabidopsis thaliana, Kluyveromyces lactis, Schizosaccharomyces pombe and Drosophila melanogaster, respectively.
AVAILABILITY
Database of Eukaryotic ORIs (DeOri) can be accessed from http://tubic.tju.edu.cn/deori/