The Role of Semaphorin 3A in Bone Remodeling.
The Role of Semaphorin 3A in Bone Remodeling.
复制标题
Semaphorin 3A 在骨重塑中的作用
DOI：
10.3389/fncel.2017.00040
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发表时间：
2017
影响因子：
5.3
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Li Z;Hao J;Duan X;Wu N;Zhou Z;Yang F;Li J;Zhao Z;Huang S
骨重建发生在整个成年生活的骨表面，并与骨的数量和质量相关。这一过程是成骨细胞骨形成和成骨细胞骨吸收之间的平衡，两者相互交叉。Semaphorin 3A是一种膜相关分泌蛋白，被认为是一种可扩散的轴突化学排斥剂，参与骨吸收和骨形成的同步过程。然而，脑信号蛋白3A在骨稳态和疾病中的作用仍然难以捉摸，特别是与成骨细胞和破骨细胞的关联。本文就Semaphorin 3A在骨量、骨内环境稳定及疾病中的研究进展作一综述，并探讨其在神经性骨再生中的新应用。这将有助于理解Semaphorin 3A在骨骼生物学中的作用，并为骨骼疾病的调节和潜在治疗提供新的思路。
Bone remodeling occurs at the bone surface throughout adult life and associates bony quantity and quality. This process is a balance between the osteoblastic bone formation and osteoclastic bone resorption, which cross-talks together. Semaphorin 3A is a membrane-associated secreted protein and regarded as a diffusible axonal chemorepellent, which has been identified in the involvement of bone resorption and formation synchronously. However, the role of Semaphorin 3A in bone homeostasis and diseases remains elusive, in particular the association to osteoblasts and osteoclasts. In this review article, we summarize recent progress of Semaphorin 3A in the bone mass, homeostasis, and diseases and discuss the novel application of nerve-based bone regeneration. This will facilitate the understanding of Semaphorin 3A in skeletal biology and shed new light on the modulation and potential treatment in the bone disorders.