Chemical space and biology
Chemical space and biology
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DOI：
10.1038/nature03192
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发表时间：
2004-12-16
期刊：
影响因子：
64.8
通讯作者：
Dobson, CM
中科院分区：
文献类型：
--
作者：
Dobson, CM
化学空间--包括所有可能的有机小分子，包括存在于生物系统中的那些--是巨大的。如此巨大，事实上，到目前为止，只有一小部分被探索过。尽管如此，这些探索极大地提高了我们对生物学的理解，并导致了今天许多药物的开发。通过更深入地了解与生物学相关的化学空间区域的性质，新的生物活性分子的发现将促进我们对生物过程的了解，并导致治疗疾病的新策略。
Chemical space - which encompasses all possible small organic molecules, including those present in biological systems - is vast. So vast, in fact, that so far only a tiny fraction of it has been explored. Nevertheless, these explorations have greatly enhanced our understanding of biology, and have led to the development of many of today's drugs. The discovery of new bioactive molecules, facilitated by a deeper understanding of the nature of the regions of chemical space that are relevant to biology, will advance our knowledge of biological processes and lead to new strategies to treat disease.