1H, 13C, 15N backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form
1H, 13C, 15N backbone and side-chain resonance assignments of the human adenylate kinase 1 in apo form
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DOI：
10.1007/s12104-012-9399-5
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发表时间：
2013-10-01
影响因子：
0.9
通讯作者：
Lin, Donghai
中科院分区：
文献类型：
--
作者：
Fu, Cuiping;Peng, Yu;Lin, Donghai
AK1（腺苷酸激酶 1）在细胞磷酸转移网络、神经元成熟和再生、ABC 转运蛋白 CFTR 门控、肿瘤细胞代谢和心肌能量稳态等过程中发挥着至关重要的作用。在这里，我们报告了 apo 形式的人 AK1 蛋白的 H-1、N-15 和 C-13 主链和侧链共振分配。该工作为hAK1的进一步结构测定奠定了必要的基础。
AK1 (Adenylate Kinase 1) plays crucial roles in processes such as cellular phosphotransfer networks, neuronal maturation and regeneration, gating of ABC transporter CFTR, tumor cell metabolism and myocardial energetic homeostasis. Here we report H-1, N-15 and C-13 backbone and side-chain resonance assignments of the human AK1 protein in apo form. This work lays the essential basis for the further structure determination of hAK1.