TISSUE CONCENTRATIONS OF LEVONORGESTREL IN WOMEN USING A LEVONORGESTREL-RELEASING IUD
TISSUE CONCENTRATIONS OF LEVONORGESTREL IN WOMEN USING A LEVONORGESTREL-RELEASING IUD
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DOI：
10.1111/j.1365-2265.1982.tb01625.x
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发表时间：
1982-01-01
影响因子：
3.2
通讯作者：
LUUKKAINEN, T
中科院分区：
文献类型：
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作者：
NILSSON, CG;HAUKKAMAA, M;LUUKKAINEN, T
13名计划进行子宫切除术的妇女自愿参加了这项研究。9名妇女在手术前36至49天插入左炔诺孕酮释放宫内避孕器（IUD），4名妇女在手术前7天口服左炔诺孕酮治疗。手术切除子宫后，获得子宫内膜、子宫肌层、输卵管和脂肪组织的样品。开发了测量左炔诺孕酮组织浓度的方法，并研究了体外脂肪组织对左炔诺孕酮的摄取。子宫肌层、输卵管和脂肪组织中左炔诺孕酮的浓度在IUD组和口服治疗组中均为1 - 5 ng/g组织湿重。在子宫内膜中，IUD组的左炔诺孕酮浓度高出许多倍。体外实验表明，在使用的浓度下，左炔诺孕酮的快速摄取和类固醇对脂肪组织的不饱和性。左炔诺孕酮的脂肪组织浓度与血浆浓度相关。
Thirteen women who were scheduled for hysterectomy volunteered for the study. Nine women had a levonorgestrel-releasing intrauterine contraceptive device (IUD) inserted between 36 and 49 days prior to surgery and 4 women were on oral levonorgestrel treatment for 7 days prior to surgery. After the surgical removal of the uterus, samples of endometrial, myometrial, fallopian tube and fat tissue were obtained. Methods for measuring tissue concentrations of levonorgestrel were developed and the uptake of levonorgestrel by fat tissue in vitro was studied. The concentrations of levonorgestrel in myometrial, fallopian tube and fat tissue were all of the same order, of between 1 and 5 ng/g of wet wt of tissue, in both the IUD group and the orally treated group. In the endometrium the levonorgestrel concentrations were many-fold higher in the IUD group. The in vitro experiments showed a rapid uptake of levonorgestrel and an unsaturability of the fat tissue by the steroid at the concentrations used. The fat tissue concentrations of levonorgestrel correlated with the plasma concentrations.