Menstrual Cycle Characteristics and Vulvodynia.
Menstrual Cycle Characteristics and Vulvodynia.
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月经周期特征和外阴痛。
DOI：
10.1089/jwh.2020.9011
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Harlow,BernardL
中科院分区：
文献类型：
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作者：
Estibeiro,Vanessa;Juntunen,Allison;Bond,JuliaC;Harlow,BernardL
目的：月经周期可能通过激素途径或月经或月经卫生引起的外阴刺激影响外阴疼痛。我们评估了月经周期的特点，在那些与临床确诊vulvodynia.Materials和方法：参与者被招募从行政数据库的医疗保健网络服务27%的明尼阿波利斯-圣保罗居民。对于220例临床确诊病例和224例对照，在三个时间点回顾性评估了月经周期特征：18岁之前，外阴疼痛发作前一年和参与研究前3个月。Logistic回归用于计算所有三个时间点的月经特征与外阴痛之间关联的比值比（OR）和95%置信区间（CI）。模型调整预先指定的混杂因素进行了评估，对粗effectestimation.Results：女性月经量较重的外阴痛的几率较高的女性相比，月经量较轻的青春期（OR 1.62，95%CI 0.91-2.86），发病前一年的外阴痛（OR = 2.11，95%CI 1.10-4.02），并在3个月前研究参与（OR = 1.67，95%CI 0.91-3.06）。在青少年时期，与没有或轻微抽筋的女性相比，抽筋更严重的女性患外阴痛的几率也更高（OR = 2.45，95%CI 1.45-4.15），外阴疼痛发作前一年（OR = 3.30，95% CI 1.67-6.51），以及参与研究前3个月（OR = 4.96，95% CI 1.99-12.36）。有特定经前症状的女性也报告了外阴痛的更高几率。在外阴疼痛的患者中，有一半的人报告在月经周期中外阴疼痛的变化，其中60%的人报告在月经前和月经期间疼痛更大。此外，我们观察到一个趋势，减少使用和增加使用卫生巾的女性外阴痛接近他们的dateofdiagnosis.Conclusions：月经周期特征与外阴痛，协会是一致的，在不同阶段的生殖生命周期。
Objective:The menstrual cycle may influence vulvodynia through hormonal pathways or vulvar irritation due to menstruation or menstrual hygiene. We assessed menstrual cycle characteristics in those with and without clinically confirmed vulvodynia.Materials and Methods:Participants were recruited from the administrative database of a health care network serving ∼27% of Minneapolis–Saint Paul residents. For 220 clinically confirmed cases and 224 controls, menstrual cycle characteristics were retrospectively assessed at three time points: before age 18, the year before onset of vulvar pain, and 3 months before study participation. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between menstrual characteristics at all three time points and vulvodynia. Models adjusted for prespecified confounders were evaluated against crude effect estimates.Results:Women with heavier menstrual flows had higher odds of vulvodynia compared with women with lighter menstrual flows during their adolescent years (OR 1.62, 95% CI 0.91–2.86), the year before onset of vulvar pain (OR = 2.11, 95% CI 1.10–4.02), and during the 3 months before study participation (OR = 1.67, 95% CI 0.91–3.06). Women with more severe cramps also had higher odds of vulvodynia compared with women with no or mild cramps during their adolescent years (OR = 2.45, 95% CI 1.45–4.15), the year before onset of vulvar pain (OR = 3.30, 95% CI 1.67–6.51), and during the 3 months before study participation (OR = 4.96, 95% CI 1.99–12.36). Women with specific premenstrual symptoms also reported higher odds of vulvodynia. Among those with vulvodynia, half reported a change in vulvar pain across the menstrual cycle, with 60% of these reporting greater pain just before and during menstruation. Furthermore, we observe a trend of decreased tampon use and increased use of sanitary pads as women with vulvodynia moved closer to their date of diagnosis.Conclusions:Menstrual cycle characteristics were associated with vulvodynia, and associations were consistent across different phases of the reproductive life cycle.