The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study
The Effect of Diabetes and Prediabetes on Antituberculosis Treatment Outcomes: A Multicenter Prospective Cohort Study
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DOI：
10.1093/infdis/jiab427
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发表时间：
2021-10-27
影响因子：
6.4
通讯作者：
Andrade, Bruno B.
中科院分区：
文献类型：
--
作者：
Arriaga, Maria B.;Araujo-Pereira, Mariana;Andrade, Bruno B.
背景资料。目前尚不清楚糖尿病或糖尿病前期是否会影响结核病患者的不良治疗结果和死亡率。参加结核病区域前瞻性观察研究(报告)的培养确认、药物敏感的PWTB-2015至2019年巴西队列(N=643)根据基线糖化血红蛋白根据血糖状况进行分层。不利的结核病结局被定义为治疗失败或修改、复发或死亡；良好结局被定义为治愈或治疗完成。我们使用PWTB在2015-2019年向巴西国家疾病通报系统(SINAN)报告的数据证实了这一发现(N=20989)。Logistic回归模型评估了血糖状况和结果之间的关联。在这两个队列中，在单因素分析中，不良结果更多地与吸烟、非法药物使用和人类免疫缺陷病毒感染有关。在巴西的报告中，糖尿病，而不是糖尿病前期与不良结局有关(调整后的相对风险[ARR]，2.45；P
Background. It is unclear whether diabetes or prediabetes affects unfavorable treatment outcomes and death in people with tuberculosis (PWTB).Methods. Culture-confirmed, drug-susceptible PWTB, enrolled in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort between 2015 and 2019 (N = 643) were stratified based on glycemic status according to baseline glycated hemoglobin. Unfavorable tuberculosis (TB) outcome was defined as treatment failure or modification, recurrence, or death; favorable outcome was cure or treatment completion. We corroborated the findings using data from PWTB reported to the Brazilian National System of Diseases Notification (SINAN) during 2015-2019 (N = 20 989). Logistic regression models evaluated associations between glycemic status and outcomes.Results. In both cohorts, in univariate analysis, unfavorable outcomes were more frequently associated with smoking, illicit drug use, and human immunodeficiency virus infection. Diabetes, but not prediabetes, was associated with unfavorable outcomes in the RePORT-Brazil (adjusted relative risk [aRR], 2.45; P