A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons
A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons
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DOI：
10.1126/science.275.5297.209
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发表时间：
1997-01-10
期刊：
影响因子：
56.9
通讯作者：
Johnston, D
中科院分区：
文献类型：
--
作者：
Magee, JC;Johnston, D
应用树突斑片记录和同步钙成像技术，研究了反向传播树突状细胞动作电位在CA1神经元长时程增强(LTP)诱导中的作用。阈值下兴奋性突触后电位(EPSPS)与反向传播动作电位配对可引起突触传入部位附近树突状动作电位的放大和钙内流。这种配对也导致了强健的LTP，当EPSP与非反向传播动作电位配对或当刺激不配对时，LTP被降低。因此，动作电位为突触强度的Hebbian修饰的树突提供了突触控制的、关联的信号。
The role of back-propagating dendritic action potentials in the induction of long-term potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings and simultaneous calcium imaging. Pairing of subthreshold excitatory postsynaptic potentials (EPSPs) with back-propagating action potentials resulted in an amplification of dendritic action potentials and evoked calcium influx near the site of synaptic input. This pairing also induced a robust LTP, which was reduced when EPSPs were paired with non-back-propagating action potentials or when stimuli were unpaired. Action potentials thus provide a synaptically controlled, associative signal to the dendrites for Hebbian modifications of synaptic strength.