Making sense of latent TGFbeta activation.
Making sense of latent TGFbeta activation.
复制标题
DOI：
--
复制
发表时间：
2003
影响因子：
4
通讯作者：
J. Annes;J. Munger;D. Rifkin
中科院分区：
文献类型：
--
作者：
J. Annes;J. Munger;D. Rifkin
TGF β作为靶向细胞外基质的潜在复合物的一部分分泌。各种分子，“TGF β激活剂”，从其潜伏状态释放TGF β。TGF-β合成和作用的不寻常的时间不连续性以及TGF-β作用的全面性有助于对TGF-β的兴趣。然而，TGF β合成、储存和作用之间的逻辑联系尚不清楚。我们认为潜在的TGF β复合物作为一种细胞外传感器，其中TGF β前肽作为检测器，潜在的TGF β结合蛋白（LTBP）作为定位器，TGF-β作为效应器。这种观点为TGF β生物学的各个方面提供了逻辑连续性，并使我们能够从新的角度欣赏TGF β生物学。
TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix. A variety of molecules, 'TGFbeta activators,' release TGFbeta from its latent state. The unusual temporal discontinuity of TGFbeta synthesis and action and the panoply of TGFbeta effects contribute to the interest in TGF-beta. However, the logical connections between TGFbeta synthesis, storage and action are obscure. We consider the latent TGFbeta complex as an extracellular sensor in which the TGFbeta propeptide functions as the detector, latent-TGFbeta-binding protein (LTBP) functions as the localizer, and TGF-beta functions as the effector. Such a view provides a logical continuity for various aspects of TGFbeta biology and allows us to appreciate TGFbeta biology from a new perspective.