Next generation biofuel engineering in prokaryotes.

Next generation biofuel engineering in prokaryotes.
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DOI:
10.1016/j.cbpa.2013.03.037
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发表时间:
2013-06
影响因子:
7.8
通讯作者:
Liao, James C.
Liao, James C.
中科院分区:
生物学2区
文献类型:
--
作者:
Gronenberg, Luisa S.;Marcheschi, Ryan J.;Liao, James C.

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下一代生物燃料必须与目前的运输基础设施相适应,并来自不与粮食作物竞争的环境上可持续的资源。许多细菌物种具有有利于生产这种下一代燃料的独特性质。然而,没有一个单一的物种拥有从植物废料或二氧化碳中生产大量燃料所需的所有特性。包含所需特征子集的物种被用作具有所有所需属性的工程生物的起点。模式生物的代谢工程已经产生了高级燃料的高效价生产,包括醇、类异戊二烯和脂肪酸衍生物。技术的发展现在允许对天然燃料生产者以及木质纤维素分解菌和自养菌进行工程改造,以生产生物燃料。需要在多个方面进行持续研究,以设计生物体,实现真正可持续和经济的生物燃料生产。
Next-generation biofuels must be compatible with current transportation infrastructure and be derived from environmentally sustainable resources that do not compete with food crops. Many bacterial species have unique properties advantageous to the production of such next-generation fuels. However, no single species possesses all characteristics necessary to make high quantities of fuels from plant waste or CO2. Species containing a subset of the desired characteristics are used as starting points for engineering organisms with all desired attributes. Metabolic engineering of model organisms has yielded high titer production of advanced fuels, including alcohols, isoprenoids and fatty acid derivatives. Technical developments now allow engineering of native fuel producers, as well as lignocellulolytic and autotrophic bacteria, for the production of biofuels. Continued research on multiple fronts is required to engineer organisms for truly sustainable and economical biofuel production.
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