Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells.
Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells.
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小细胞肺癌、胎儿支气管内分泌细胞和其他神经内分泌细胞表达自然杀伤细胞上存在的 Leu-7 抗原决定簇。
作者：
P. Bunn;I. Linnoila;J. Minna;D. Carney;A. Gazdar
小细胞肺癌与其他肺癌组织学类型的区别在于具有多种神经内分泌特性。抗Leu-7是一种单克隆抗体，其识别110，000-道尔顿分子量的糖蛋白，最初在自然杀伤细胞上描述，随后在多种正常和恶性神经和神经内分泌细胞类型上报道。我们已经发现大量小细胞肺癌与抗Leu-7强烈结合，而其他肺癌类型为阴性或仅显示弱的局灶性结合。自然杀伤细胞、淋巴细胞和单核细胞表达的其他抗原在小细胞肺癌细胞上从不表达或较少表达。此外，我们首次报告抗Leu-7结合类癌，颈动脉体瘤，嗜铬细胞瘤，胎儿支气管和成人肠内分泌细胞，并选择胰岛细胞。小细胞肺癌的抗Leu-7结合与肺前体细胞的衍生一致，并且抗Leu-7染色在临床上可用于鉴定胺前体摄取和脱羧（“APUD”）类型的人神经内分泌肿瘤。
Small cell lung cancer is distinguished from other lung cancer histologic types by possessing a variety of neuroendocrine properties. Anti-Leu-7 is a monoclonal antibody that recognizes a 110,000-dalton molecular weight glycoprotein initially described on natural killer cells and subsequently reported on a variety of normal and malignant neural and neuroendocrine cell types. We have found intense anti-Leu-7 binding to a large number of small cell lung cancers, while other lung cancer types were negative or showed only weak and focal binding. Other antigens expressed by natural killer cells, lymphocytes, and monocytes were never or less often expressed on small cell lung cancer cells. In addition, we report for the first time anti-Leu-7 binding by carcinoids, carotid body tumors, pheochromocytomas, endocrine cells of the fetal bronchus and the adult intestine, and select pancreatic islet cells. Anti-Leu-7 binding by small cell lung cancer is consistent with a derivation from pulmonary precursor cells, and anti-Leu-7 staining is clinically useful for the identification of human neuroendocrine tumors of the amine precursor uptake and decarboxylation ("APUD") type.