Structure and mechanism of energy-coupling factor transporters
Structure and mechanism of energy-coupling factor transporters
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能量耦合因子转运蛋白的结构和机制
DOI：
10.1016/j.tim.2013.09.009
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发表时间：
2013
影响因子：
15.9
通讯作者：
Zhang Peng
中科院分区：
文献类型：
--
作者：
Zhang Peng
能量偶联因子（ECF）转运蛋白是ATP结合盒（ABC）转运蛋白的一个新家族，被原核生物广泛用于从环境中摄取微量营养素。ECF转运蛋白不使用周质溶质结合蛋白（SBP），而是使用膜S蛋白进行底物捕获和转运。在本次综述中，我们将重点关注ECF转运蛋白如何识别底物以及ECF转运蛋白采用的可能转运机制方面所取得的结构性进展。
Energy-coupling factor (ECF) transporters form a new family of ATP-binding cassette (ABC) transporters and are widely used by prokaryotes to take up micronutrients from the environment. Instead of using the periplasmic solute-binding proteins (SBPs), ECF transporters use the membrane S proteins for substrate capture and translocation. In this review, we will focus on structural advances that have been made regarding how substrates are recognized by ECF transporters and possible transport mechanisms employed by the ECF transporters.