Risk of rupture of the cerebral aneurysm in relation to traumatic brain injury using a patient-specific fluid-structure interaction model
Risk of rupture of the cerebral aneurysm in relation to traumatic brain injury using a patient-specific fluid-structure interaction model
复制标题
使用患者特定的流体-结构相互作用模型研究与创伤性脑损伤相关的脑动脉瘤破裂风险
DOI：
10.1016/j.cmpb.2019.04.015
复制
发表时间：
2019
影响因子：
6.1
通讯作者：
A. Karimi
中科院分区：
文献类型：
--
作者：
R. Razaghi;H. Biglari;A. Karimi
背景与目的脑动脉瘤是指脑内动脉壁的一个薄弱区域，当血管壁张力超过其机械强度时破裂。创伤性脑损伤（Traumatic brain injury，TBI）是通过对脑施加突然的冲击载荷而引起的脑血管的机械性损伤，其后果不仅是脑血管结构的改变，而且是脑血管功能的改变。TBI还改变脑血管中血流的血液动力学，同时已经表明血液动力学在脑动脉瘤的进展和破裂中具有关键作用。到目前为止，缺乏关于脑动脉瘤破裂与TBI相关风险的知识。因此，本研究旨在使用位于Willis环前循环区域的脑动脉瘤的流体-结构相互作用（FSI）模型来计算动脉壁中的机械应力和变形以及血液的压力和速度。建立了一个使用人类计算机断层扫描（CT）/磁共振成像（MRI）的数据，并进行了额TBI。结果显示，相当大的增加1.8 kPa（60 mmHg）和0.40 m/s，脑外伤后脑动脉腔内血流速度和压力的变化。脑动脉瘤壁的von Mises应力、剪切应力和变形也显示了TBI后分别增加了56.03 kPa、15.66 Pa和0.072 mm，ConclusionsAlthough TBI后对动脉瘤壁的损伤低于动脉瘤壁的机械强度，但它仍然可以改变壁中的应力模式，扰乱血液的血流动力学。这些结果在理解脑动脉瘤破裂的风险，由于创伤性脑损伤，这可能有助于建立预防和/或治疗方法的影响。
Background and objectiveCerebral aneurysm, which is defined as one of the weakened area in the wall of an artery in the brain, ruptures when wall tension exceeds its mechanical strength. Traumatic brain injury (TBI) by exerting a sudden impact load to the brain can lead to mechanical failure of the cerebral blood vessels followed by an alteration in not only the structure but also the function of the cerebrovascular. TBI also alters the hemodynamics of the blood flow in the cerebrovascular, while it has been shown that hemodynamics has a key asset in the progression and rupture of the cerebral aneurysms. So far, there is a lack of knowledge on the risk of rupture of the cerebral aneurysm in relation to TBI. Therefore, this study aimed to calculate the mechanical stresses and deformations in the arterial wall as well as the pressure and velocity of the blood using a fluid-structure interaction (FSI) model of the cerebral aneurysm located in the anterior circulation region of the circle of Willis.MethodA patient-specific FSI model of the human skull, brain, and cerebral aneurysm, was established using human computed tomography (CT)/ magnetic resonance imaging (MRI) data and subjected to a frontal TBI.ResultsThe results revealed considerable increasing of ∼ 8 kPa (60 mmHg) and 0.40 m/s in the pressure and velocity of the blood in the intraluminal of the cerebral artery after TBI. The von Mises stress, shear stress, and deformation of the cerebral aneurysm wall also showed the increasing of 56.03 kPa, 15.66 Pa, and 0.072 mm after TBI, respectively.ConclusionsAlthough the injury to the aneurysm wall after TBI is lower than that of the aneurysm wall mechanical strength, it still can alter the stress pattern in the wall and disrupt the hemodynamics of the blood. These results have implications in understanding the rupture risk of the cerebral aneurysm due to TBI, which may contribute in establishing preventive and/or treatment methods.
DOI：
--
发表时间：
2005-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
L. Jou;G. Wong;B. Dispensa;M. Lawton;R. Higashida;W. Young;D. Saloner
通讯作者：
L. Jou;G. Wong;B. Dispensa;M. Lawton;R. Higashida;W. Young;D. Saloner
影响因子：
4.2
作者：
Simard, J. Marc;Kilbourne, Michael;Gerzanich, Volodymyr
通讯作者：
Gerzanich, Volodymyr
诱导氧化和亚硝化损伤会导致脑血管炎症，这是由原发性爆炸引起的轻度外伤性脑损伤的动物模型。
影响因子：
7.4
作者：
Abdul-Muneer, P. M.;Schuetz, Heather;Wang, Fang;Skotak, Maciej;Jones, Joselyn;Gorantla, Santhi;Zimmerman, Matthew C.;Chandra, Namas;Haorah, James
通讯作者：
Haorah, James