Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus.
Nucleotide sequence analyses of the genes encoding the HN, M, NP, P, and L proteins of two host range mutants of Sendai virus.
复制标题
对仙台病毒两个宿主范围突变体的 HN、M、NP、P 和 L 蛋白编码基因的核苷酸序列分析。
DOI：
10.1016/0042-6822(90)90040-x
复制
发表时间：
1990
期刊：
影响因子：
3.7
通讯作者：
Seto,JT
中科院分区：
文献类型：
--
作者：
Middleton,Y;Tashiro,M;Thai,T;Oh,J;Seymour,J;Pritzer,E;Klenk,HD;Rott,R;Seto,JT
仙台病毒（Z株）和两个宿主范围的突变体，ts-f1和F1-R，先前描述的基因组的比较核苷酸序列分析表明，是缺陷的ts-f1可以归因于两个核苷酸交换的NP基因。这些交换导致单个氨基酸取代。在F1-R的P和L基因中发现了一个单碱基对的变化，但ts-f1没有。两种寄主范围突变体在M基因上都有两个相同的交换。这些额外的突变进行了讨论，其意义的泛热带性质的主机范围突变体。
Comparative nucleotide sequence analyses of the genome of Sendai virus (strain Z) and two host range mutants, ts-f1 and F1-R, previously described revealed that the is defect of ts-f1 can be attributed to two nucleotide exchanges in the NP gene. These exchanges lead to a single amino acid substitution. A single base pair change was found in both the P and L genes of F1-R, but not of ts-f1. Both host range mutants have the two same exchanges in the M gene. These additional mutations are discussed concerning their significance in the pantropic properties of the host range mutants.