PULMONARY CAPILLARY BLOOD VOLUME, FLOW AND DIFFUSING CAPACITY DURING EXERCISE
PULMONARY CAPILLARY BLOOD VOLUME, FLOW AND DIFFUSING CAPACITY DURING EXERCISE
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DOI：
10.1152/jappl.1960.15.5.893
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发表时间：
1960-01-01
影响因子：
3.3
通讯作者：
FORSTER, RE
中科院分区：
文献类型：
--
作者：
JOHNSON, RL;SPICER, WS;FORSTER, RE
肺毛细血管血流量（Qc）和表观CO弥散量（DI）的消失率的吸入乙炔和一氧化碳在屏气过程中的肺泡小浓度计算。在四名正常受试者同时进行这样的测量，在休息时，在运动中，而执行Valsalva或Mueller演习，他们也在一个以上的肺泡氧分压，使真正的膜扩散能力（Dm）和肺毛细血管血容量（Vc）可以计算的方法劳顿和福斯特。Dl、Dm和Vc与Qc密切相关（r分别为0.92、0.71和0.92），表明肺毛细血管床的容积和有效表面积均随血流方向的改变而沿着变化。在开始或停止运动后的瞬变期间，DL的变化略微滞后于Qc的相关变化;然而，在稳定运动约1分钟后，两个参数趋于达到稳定值。静息状态下红细胞在肺毛细血管中所花费的平均时间估计为0.79秒，在运动水平下下降到约0.5秒，此时通过毛细血管床的体积流量约为三倍。
Pulmonary capillary blood flow (Qc) and apparent CO diffusing capacity (Dl) were calculated from the rates of disappearance of small alveolar concentrations of inspired acetylene and carbon monoxide during breath holding. Such measurements were performed simultaneously in four normal subjects at rest, during exercise and while performing Valsalva or Mueller maneuvers; they were also made at more than one alveolar oxygen tension so that true membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) could be calculated by the method of Roughton and Foster. Dl, Dm and Vc were closely correlated with Qc (r = 0.92, 0.71 and 0.92, respectively), indicating that both volume and effective surface of the pulmonary capillary bed changed along with corresponding directional changes in blood flow. During transients after starting or after stopping exercise, changes in DL lagged slightly behind the associated changes in Qc; both parameters tended to reach steady values, however, after about 1 minute of steady exercise. The average time spent by red cells in the pulmonary capillaries at rest was estimated to be 0.79 second, falling to about 0.5 second at levels of exercise at which volume flow through th*e capillary bed was approximately tripled.