Environmental assessment of cytotoxic drugs in healthcare settings: protocol for a systematic review and meta-analysis.
Environmental assessment of cytotoxic drugs in healthcare settings: protocol for a systematic review and meta-analysis.
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DOI：
10.1186/s13643-020-01494-4
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发表时间：
2020-10-19
影响因子：
3.7
通讯作者：
Al-Rifai RH
中科院分区：
文献类型：
--
作者：
Al Alawi L;Soteriades ES;Paulo MS;Östlundh L;Grivna M;Al Maskari F;Al-Rifai RH
职业接触细胞毒性药物与各种不利的健康结果有关。本方案报告了一种系统评价和荟萃分析的方法，旨在系统地回顾已发表的文献并量化医疗机构使用细胞毒性药物的环境污染水平。本方案是根据2015年系统评价和荟萃分析方案首选报告项目（PRISMA-P）指南制定的。检索六个电子数据库（PubMed, Web of Science, Scopus, Cochrane Library， CINAHL， EMBASE），不限制出版期限。将确定符合条件的研究，并由至少两名独立审稿人按照最佳实践使用预定义的数据提取表提取数据。符合条件的研究应报告经计算或可计算的细胞毒性药物阳性样本比例估计和/或测试样本中细胞毒性药物浓度估计。将使用世界卫生组织（WHO）和国际劳工组织（ILO）为环境和职业健康系统评价而开发的职业风险因素暴露流行率研究（robo - speo）工具来评估偏倚风险（RoB）。随机效应模型将被用于进行meta分析。职业接触细胞毒性药物与短期和长期不良健康结果相关。按照这一方案，将要进行的审查将是第一个填补关于细胞毒性药物对卫生保健环境污染的证据空白的审查。本综述的发现将有助于了解卫生保健工作者职业暴露于细胞毒性药物的风险，并有助于确定具体干预的优先领域。由于研究设计的性质，系统评价方法不需要伦理批准。系统评价的结果将发表在同行评议的期刊上，并向公众开放。PROSPERO CRD42020162780，日期为2020年7月14日
Occupational exposure to cytotoxic drugs is associated with various unfavorable health outcomes. This protocol reports a methodology for a systematic review and meta-analysis that aims to systematically review the published literature and quantify the level of environmental contamination of healthcare settings with cytotoxic drugs. This protocol is developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol-2015 (PRISMA-P) guidelines. Six electronic databases (PubMed, Web of Science, Scopus, Cochrane Library, CINAHL, and EMBASE) will be searched with no restrictions on publication period. Eligible studies will be identified and data will be extracted using a predefined data extraction form by at least two independent reviewers following best practice. Eligible studies should report calculated or calculable estimates on the proportion of positive samples tested for cytotoxic drugs and/or estimates on the concentration of the cytotoxic drug(s) in the tested samples. Risk of bias (RoB) will be assessed by using the RoB in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool, which developed by the World Health Organization (WHO) and International Labour Organization (ILO) for environmental and occupational health systematic reviews. The random-effects model will be used to perform meta-analyses. Occupational exposure to cytotoxic drugs is associated with short- and long-term adverse health outcomes. Following this protocol, the review to be carried out will be the first to fill an evidence gap on the environmental contamination of healthcare settings with cytotoxic drugs. The findings of this review will help in the understanding of the risk of occupational exposure of healthcare workers to cytotoxic drugs and facilitate the identification of priority areas for specific interventions. The systematic review methodology does not require ethics approval due to the nature of the study design. The results of the systematic review will be published in a peer-reviewed journal and will be publicly available. PROSPERO CRD42020162780, dated July 14, 2020
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
15.8
作者：
Liberati A;Altman DG;Tetzlaff J;Mulrow C;Gøtzsche PC;Ioannidis JP;Clarke M;Devereaux PJ;Kleijnen J;Moher D
通讯作者：
Moher D
影响因子：
10.4
作者：
Woodruff TJ;Sutton P
通讯作者：
Sutton P
影响因子：
9.8
作者：
Lawson, Christina C.;Rocheleau, Carissa M.;Rich-Edwards, Janet W.
通讯作者：
Rich-Edwards, Janet W.
影响因子：
1.3
作者：
Sessink, Paul J. M.;Leclercq, Gisele M.;Kassoul, Nassima
通讯作者：
Kassoul, Nassima