Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits
Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits
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DOI：
10.1016/j.celrep.2018.06.053
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发表时间：
2018-07-10
期刊：
影响因子：
8.8
通讯作者：
Luthi, Andreas
中科院分区：
文献类型：
--
作者：
Lavi, Karen;Jacobson, Gilad A.;Luthi, Andreas
通过条件性味觉厌恶来避免潜在有毒的食物对于许多动物的生存至关重要。然而，人们对潜在的神经机制知之甚少。在这里，利用体内确定的味觉皮层神经元的双光子钙成像，我们发现条件性味觉厌恶通过刺激特异性招募投射到基底外侧杏仁核的神经元来动态改变神经元群体编码。
Avoidance of potentially toxic food by means of conditioned taste aversion is critical for survival of many animals. However, the underlying neuronal mechanisms are poorly understood. Here, using two-photon calcium imaging of defined gustatory cortex neurons in vivo, we show that conditioned taste aversion dynamically shifts neuronal population coding by stimulus-specific recruitment of neurons that project to the basolateral amygdala.