Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial
Evaluation of Efficacy of an Herbal Compound on Dry Mouth in Patients With Head and Neck Cancers: A Randomized Clinical Trial
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DOI：
10.1177/2156587215590232
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发表时间：
2016-01-01
影响因子：
3.5
通讯作者：
Gachkar, Latif
中科院分区：
文献类型：
--
作者：
Ameri, Ahmad;Heydarirad, Ghazaleh;Gachkar, Latif
口干是头颈癌放射治疗的常见并发症。这项研究比较了含有锦葵和指状藻 (Boiss) 的草药化合物与人工唾液 (Hypozalix) 在改善头颈癌患者口干症状方面的功效。该研究总共检查了 62 名受试者，分为 2 个组。草药化合物和 Hypozalix 服用 4 周。使用视觉模拟量表并通过对口干程度进行分级来评估功效。两组在干预前后视觉模拟量表均表现出显着差异。干预开始后 4 周，各组之间的视觉模拟量表也存在显着差异。草药组干预前后口干程度存在显着差异，但 Hypozalix 组口干程度没有变化。这项研究支持草药化合物对于控制头颈癌患者口干症状的功效。
Dry mouth is a common complication of radiotherapy for head and neck cancers. This study compared the efficacy of an herbal compound containing Malva sylvestris and Alcea digitata (Boiss) with artificial saliva (Hypozalix) for improving the symptoms of dry mouth in head and neck cancer patients. The study examined a total of 62 subjects assigned to 2 groups. The herbal compound and Hypozalix were administered for 4 weeks. Efficacy was assessed using the visual analog scale and by grading the degree of dry mouth. Both groups showed a significant difference between visual analog scale before and following intervention. There was also a significant difference in visual analog scale between groups at 4 weeks after onset of intervention. The herbal group showed a significant difference between the grade of dry mouth before and after intervention, but no change was observed for grade of dry mouth in the Hypozalix group. This study supports the efficacy of the herbal compound for controlling symptoms of dry mouth in head and neck cancer patients.