Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings
Aerobic vaginitis and mixed infections: comparison of clinical and laboratory findings
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DOI：
10.1007/s00404-012-2571-4
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发表时间：
2013-02-01
影响因子：
2.6
通讯作者：
Xue, Fengxia
中科院分区：
文献类型：
--
作者：
Fan, Aiping;Yue, Yingli;Xue, Fengxia
为了解需氧性阴道炎（AV）及其混合感染的临床特点，提高诊断率，对2008年4月至2009年8月天津医科大学总医院妇科门诊657例有阴道症状的患者进行调查。采集样本进行阴道分泌物检查和新鲜湿封片显微镜检查。根据标准化定义诊断AV、细菌性阴道病（BV）、外阴阴道念珠菌病（VVC）和滴虫性阴道炎（TV）。在同一时期随机选择60例单AV患者。所有患者均接受阿曲沙星治疗。采用400 mg qd，6 d或400 mg qd，12 d 2个疗程。对657例患者的临床表现、实验室检查结果进行统计学分析，发现AV占23.74%（156/657）。AV混合感染占53.85%（84/156），其中VVC（32/84，38.10%），BV（31/84，36.90%），TV（21/84，25.00%）。AV的常见症状为放电特征改变（44/72，61.11%）和放电增多（30/72，41.67%）。阴道pH> 4.5者占87.50%（63/72）。粪肠球菌、草绿色链球菌、大肠杆菌和表皮葡萄球菌是常见的分离菌。两组间差异无统计学意义（p > 0.05）。6天组治愈率为89. 7%，12天组治愈率为71. 4%。AV是一种常见的阴道感染，常与其他感染混合，尤以VVC、BV、TV为多。AV混合感染的症状和体征不典型。如果患者有阴道不适，有必要确定是否存在AV或混合感染。口服阿曲沙星治疗AV有效，应根据AV的严重程度选择合适的疗程。
To investigate the clinical features of aerobic vaginitis (AV) and mixed infections with AV to achieve efficient diagnosis.From April 2008 to August 2009, 657 consecutive outpatients with vaginal symptoms in gynecology clinic in the General Hospital of Tianjin Medical University were investigated. Samples were taken for examination of vaginal discharge and fresh wet mount microscopy. AV, bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomonal vaginitis (TV) were diagnosed according to standardized definitions. Sixty patients with single AV were randomly selected over the same period. Each patient accepted moxifloxacin therapy. Two kinds of treatment course (400 mg qd, 6 days or 400 mg qd, 12 days) were given. Clinical features and laboratory test results in the first visit and follow-ups were recorded and statistically analyzed.Among the 657 cases, AV was found in 23.74 % of the cases (156/657). AV mixed infections were diagnosed in 53.85 % (84/156): the mixed infections included VVC (32/84, 38.10 %), BV (31/84, 36.90 %), and TV (21/84, 25.00 %). Common symptoms of AV were a change in the characteristics of the discharge (44/72, 61.11 %) and increased discharge (30/72, 41.67 %). Vaginal pH was usually higher than 4.5 (63/72, 87.50 %). Enterococcus faecalis, Streptococcus viridans, Escherichia coli, and Staphylococcus epidermidis were frequently isolated. There is no statistically significant difference between two moxifloxacin treatment groups (p > 0.05). Cure rate was 89.7 % in 6-day group, and 71.4 % in 12-day group.AV is a common vaginal infection, and it is often mixed with other infections, especially VVC, BV and TV. The symptoms and signs of AV mixed infections are atypical. If a patient has vaginal complaints, it is necessary to determine whether AV or mixed infections are present. Oral moxifloxacin is effective in treating AV, and an appropriate course should be selected taking the severity of AV into consideration.