Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor.

Connective tissue activation. XI. Stimulation of glycosaminoglycan and DNA formation by a platelet factor.
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结缔组织激活。

DOI：
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发表时间：
1977
期刊：
Arthritis & Rheumatism
影响因子：
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通讯作者：
Whitney Sl
Whitney Sl
中科院分区：
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文献类型：
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作者：
Castor Cw;Ritchie Jc;Scott Me;Whitney Sl

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本报告描述了一种在人血小板中发现的小的碱性蛋白质，其刺激几种类型的人结缔组织细胞中的透明质酸形成、葡萄糖摄取和乳酸盐形成。此外，在人滑膜细胞培养物中，它刺激[3 H]甲基胸苷掺入DNA。这种血小板因子（结缔组织激活肽-II，CTAP-III）与在人淋巴细胞中发现的CTAP-I明显不同，可能作为炎症过程的介质发挥作用。
This report describes a small basic protein found in human platelets which stimulates hyaluronic acid formation, glucose uptake, and lactate formation in several types of human connective tissue cells. In addition, it stimulates in incorporation of [3H] methyl thymidine into DNA in human synovial cell cultures. This platelet factor (connective tissue activating peptide-II, CTAP-III) clearly differs form CTAP-I, found in human lymphocytes, and may play a role as a mediator of the inflammatory process.