Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma
Correlation between basic fibroblast growth factor immunostaining of stromal cells and stromelysin-3 mRNA expression in human breast carcinoma
复制标题
DOI：
10.1038/bjc.1998.155
复制
发表时间：
1998-03-01
影响因子：
8.8
通讯作者：
Linder, S
中科院分区：
文献类型：
--
作者：
Linder, C;Byström, P;Linder, S
我们用免疫组织化学方法检测了一系列人乳腺癌中碱性成纤维细胞生长因子（bFGF）的定位。在54个肿瘤中的15个（28%）肿瘤细胞中观察到染色，在54个检查的肿瘤中的34个（63%）相邻基质中观察到染色。在这两个隔室的阳性染色之间未观察到相关性。碱性成纤维细胞生长因子染色和金属蛋白酶基质分解素-3的表达之间的关系，和碱性成纤维细胞生长因子和微血管密度之间的关系，进行了检查。间质细胞bFGF染色与基质溶素-3（ST-3; MMP-11）金属蛋白酶mRNA高表达之间存在统计学显著相关性（P < 0.003）。相反，bFGF和肿瘤内微血管密度（IMD）之间没有相关性。这些结果提高了bFGF可能参与乳腺癌间质中基质溶解素-3 mRNA表达的诱导的可能性。
We examined the localization of basic fibroblast growth factor (bFGF) in a series of human breast carcinomas using immunohistochemistry. Staining was observed in tumour cells in 15 out of 54 (28%) tumours and in the adjacent stroma in 34 out of 54 (63%) tumours examined. No correlation was observed between positive staining of these two compartments. The relationship between bFGF staining and expression of the metalloprotease stromelysin-3, and between bFGF and microvessel density, was examined. A statistically significant correlation (P < 0.003) was observed between bFGF staining of the stromal compartment and high expression of stromelysin-3 (ST-3; MMP-11) metalloprotease mRNA by stromal cells. In contrast, no correlation was observed between bFGF and intratumour microvessel density (IMD). These results raise the possibility that bFGF may be involved in the induction of stromelysin-3 mRNA expression in breast cancer stroma.