HYDROXYPROLINE CONTENT AND LOCATION IN RELATION TO COLLAGEN THERMAL-STABILITY
HYDROXYPROLINE CONTENT AND LOCATION IN RELATION TO COLLAGEN THERMAL-STABILITY
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DOI：
10.1002/bip.1979.360180413
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发表时间：
1979-01-01
期刊：
影响因子：
2.9
通讯作者：
BURJANADZE, TV
中科院分区：
文献类型：
--
作者：
BURJANADZE, TV
对亚胺酸含量对胶原热稳定性（tm）变化的影响进行了新的分析。对于间质性脊椎动物胶原，tm随羟脯氨酸含量的变化有严格的规律性。tm与脯氨酸含量无相关性。无脊椎动物和基底膜胶原的tm与羟脯氨酸含量无相关性。tm对羟脯氨酸含量的依赖性被认为不是tm与羟脯氨酸总含量之间的相关性，而只是tm与序列中第3位（Gly-R2-R3）n的羟脯氨酸含量之间的相关性。脯氨酸和羟脯氨酸对胶原蛋白三螺旋结构稳定性的影响明显不同。
A new analysis was made on studies of the influence of imino acid content on the changes of collagen thermal stability (tm). For the interstitial vertebrate collagens, there is a strict regularity in the changes of tm depending on hydroxyproline content. No correlation is observed between tm and proline content. No correlation between tm and hydroxyproline content is observed for invertebrate and basement membrane collagens. The dependence of tm on hydroxyproline content is considered to be not a correlation between tm and the total content of hydroxyproline but only as the correlation between tm and the content of hydroxyproline occurring at the 3rd position in the sequence (Gly-R2-R3)n. The influence exerted by proline and hydroxyproline on the stabilization of the triple helix of collagen is apparently different.