Strongyloides ratti and S. venezuelensis - rodent models of Strongyloides infection.
Strongyloides ratti and S. venezuelensis - rodent models of Strongyloides infection.
复制标题
DOI：
10.1017/s0031182016000020
复制
发表时间：
2017-03
期刊：
影响因子：
2.4
通讯作者：
Kikuchi T
中科院分区：
文献类型：
--
作者：
Viney M;Kikuchi T
类圆线虫属是脊椎动物的常见寄生虫，有两种，S. ratti和S. venezuelensis寄生于大鼠;没有已知的物种自然感染小鼠。Ratti类圆线虫和S.委内瑞拉人的地理分布范围重叠，在这些地区，合并感染似乎很常见。这些种属已广泛用作大鼠和小鼠的易处理实验室系统。这两个物种的核心生物学是相似的，但在它们的宿主内生物学以及它们的自由生活世代方面存在明显的差异。系统发育证据表明，S。ratti和S.委内瑞拉圆线虫是两个独立的进化过渡到大鼠寄生的结果，因此，这提供了一个理想的机会，开始调查的基础上，宿主特异性在圆线虫属。
Strongyloides spp. are common parasites of vertebrates and two species, S. ratti and S. venezuelensis, parasitize rats; there are no known species that naturally infect mice. Strongyloides ratti and S. venezuelensis overlap in their geographical range and in these regions co-infections appear to be common. These species have been widely used as tractable laboratory systems in rats as well as mice. The core biology of these two species is similar, but there are clear differences in aspects of their within-host biology as well as in their free-living generation. Phylogenetic evidence suggests that S. ratti and S. venezuelensis are the result of two independent evolutionary transitions to parasitism of rats, which therefore presents an ideal opportunity to begin to investigate the basis of host specificity in Strongyloides spp.