IRON-ABSORPTION IN MAN - ASCORBIC-ACID AND DOSE-DEPENDENT INHIBITION BY PHYTATE
IRON-ABSORPTION IN MAN - ASCORBIC-ACID AND DOSE-DEPENDENT INHIBITION BY PHYTATE
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DOI：
10.1093/ajcn/49.1.140
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发表时间：
1989-01-01
影响因子：
7.1
通讯作者：
ROSSANDER, L
中科院分区：
文献类型：
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作者：
HALLBERG, L;BRUNE, M;ROSSANDER, L
通过食用不含肌醇六磷酸盐的小麦卷和在食用前添加不同量（以肌醇六磷酸盐磷表示，在2和250 mg之间的七个剂量水平）的小麦卷，研究了肌醇六磷酸钠对人体铁吸收的剂量依赖性抑制作用。用两种放射性同位素Fe（55 Fe、59 Fe）标记两种卷中的Fe，隔日供应。铁吸收的抑制与添加植酸盐的量密切相关; 2 mg抑制吸收18%（p < 0.001），25 mg抑制吸收64%（p < 0.001），250 mg抑制吸收82%（p < 0.001）。添加抗坏血酸显着抵消了抑制，而相应的影响，肉类是不太明确的，只看到在最高的植酸水平。磷酸盐对铁吸收的显著抑制作用和抗坏血酸的显著抵消作用具有广泛的营养意义。
The dose-dependent inhibitory effect of sodium phytate on iron absorption was studied in man by serving wheat rolls containing no phytates and rolls to which various amounts (seven dose levels between 2 and 250 mg expressed as phytate phosphorus) were added just before serving. Fe in the two kinds of rolls was labeled with two radioisotopes of Fe (55Fe, 59Fe) and the rolls were served on alternate days. The inhibition of Fe absorption was strongly related to the amount of phytate added; 2 mg inhibited absorption by 18%, (p < 0.001), 25 mg by 64% (p < 0.001), and 250 mg by 82% (p < 0.001). The addition of ascorbic acid significantly counteracted the inhibition whereas the corresponding effect of meat was less well defined and only seen at the highest phytate level. The marked inhibition of Fe absorption by phtates and the significant counteracting effect of ascorbic acid have wide nutritional implications.