Oncogenes in human solid tumors.
Oncogenes in human solid tumors.
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人类实体瘤中的癌基因。
DOI：
10.1007/978-1-4613-1599-5_9
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发表时间：
1989
影响因子：
--
通讯作者：
Benz,CC
中科院分区：
文献类型：
--
作者：
Rochlitz,CF;Benz,CC
在过去的十年里，我们对癌症分子起源的理解发生了巨大的变化。为此，主要的贡献来自于癌基因及其细胞对应物，原癌基因，以及隐性抑癌基因或肿瘤抑制基因的鉴定。这些一般主题已被广泛审查[1-16]。本章的目的是解决什么是已知的癌基因异常在特定的人类实体瘤，包括发病率和癌基因激活的模式，其在肿瘤形成和转移的假定作用，以及癌基因异常的临床意义与肿瘤的行为和患者预后。在关注特定的肿瘤类型之前，总结与癌基因激活相关的概念是有用的，这可能有助于理解支持癌基因在自然发生的人类肿瘤的发展或进展中的作用的现有证据。
The past decade has witnessed great changes in our understanding of the molecular origins of cancer. Toward this end, major contributions have come from the identification of oncogenes and their cellular counterparts, proto-oncogenes, as well as recessive anti-oncogenes, or tumor-suppressor genes. These general topics have been extensively reviewed [1–16]. The purpose of this chapter is to address what is known about oncogene abnormalities in specific human solid tumors, including the incidence and mode of oncogene activation, its putative role in tumor formation and metastasis, and the clinical significance of oncogene abnormalities relating to tumor behavior and patient prognosis. Before focusing on specific tumor types, it is useful to summarize those concepts pertinent to oncogene activation that might help in understanding the present evidence supporting a role for oncogenes in the development or progression of naturally occurring human tumors.