Implications of genomics for public health: the role of genetic epidemiology.
Implications of genomics for public health: the role of genetic epidemiology.
复制标题
基因组学对公共卫生的影响：遗传流行病学的作用。
DOI：
10.1101/sqb.2003.68.359
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Merikangas,KR
中科院分区：
文献类型：
--
作者：
Merikangas,KR
On the basis of family and twin studies, it is possible to identify the relative contribution of genetic and environmental factors. Evidence for environmental influences includes: discordant monozygotic twins; greater than a 50% diminution in risk in relatives than expected by degree of genetic relatedness; and greater concordance for monozygotic twins reared together compared to those reared apart. For example, our recent review of a series of complex diseases revealed that multiple sclerosis, type I diabetes, autism, and schizophrenia are more strongly influenced by genetic risk factors; breast cancer, type II diabetes, and Alzheimer’s disease are vulnerable to both genetic and environmental susceptibility; and environmental exposures are necessary for the development of alcohol and drug abuse, cervical cancer, and AIDS, but genes may determine the extent to which exposure is associated with disease, infection, or cancer (Merikangas and Risch 2003).
