Is there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper?
Is there a link between premature ovarian failure and serum concentrations of vitamin D, zinc, and copper?
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DOI：
10.1097/gme.0b013e31826015ca
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发表时间：
2013-01-01
影响因子：
2.7
通讯作者：
Taner, Cuneyt Eftal
中科院分区：
文献类型：
--
作者：
Kebapcilar, Ayse Gul;Kulaksizoglu, Mustafa;Taner, Cuneyt Eftal
目的：原发性卵巢功能不全（POI）的风险增加与自身免疫性疾病相关。充足的维生素D （vit D）和微量元素的摄入是免疫系统有效运作所必需的。本研究的目的是评估至少生过一个孩子的POI妇女和月经周期正常的妇女血液中维生素D、锌和铜的水平。方法：这是一项横断面的病例对照研究，涉及63名参与者，分为两组：研究组由35名POI女性组成，对照组由28名月经周期正常的女性组成。测定每个参与者的血清锌、维生素D和铜浓度。结果：与健康对照组相比，POI妇女血清铜水平和铜锌比显著升高，血清维生素D和锌水平显著降低。血清促卵泡激素水平与锌和维生素D水平呈负相关，与铜锌比和铜水平呈正相关。维生素D水平与促卵泡激素水平、铜锌比、铜水平呈负相关，与锌水平呈正相关。结论：大多数POI妇女缺乏维生素D。锌、铜和维生素D似乎与参与者的激素状态有关。目前的研究可能为未来的研究提供假设，这些研究将调查POI女性微量元素和维生素D缺乏变化背后的可能机制，以及这些变化是否可以用于筛查患POI的风险。
Objective: The risk of primary ovarian insufficiency (POI) increases in association with autoimmune conditions. Adequate intake of vitamin D (vit D) and trace elements is required for the immune system to function efficiently. The aim of this study was to evaluate vit D, zinc, and copper blood levels in women with POI who had given birth to at least one child and in women with normal menstrual cycles.Methods: This was a cross-sectional, case-control study involving 63 participants divided into two groups: the study group, which is composed of 35 women with POI, and the control group, which is composed of 28 women with normal menstrual cycles. Serum concentrations of zinc, vit D, and copper were determined for each participant.Results: Women with POI had significantly higher serum copper levels and copper-to-zinc ratio but significantly lower serum vit D and zinc levels when compared with the healthy control group. Serum follicle-stimulating hormone levels were inversely correlated with zinc and vit D levels and positively correlated with the copper-to-zinc ratio and copper levels. Vit D levels were inversely correlated with follicle-stimulating hormone levels, copper-to-zinc ratio, and copper levels and positively correlated with zinc levels.Conclusions: Most women with POI are deficient in vit D. Zinc, copper, and vit D seem to correlate with hormonal status in the participants. The present study may generate hypotheses for future studies that will investigate the possible mechanisms behind alterations in trace elements and vit D deficiency in women with POI and whether these changes could be used to screen for the risk of developing POI.