The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens
The adhesion receptor CD155 determines the magnitude of humoral immune responses against orally ingested antigens
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DOI：
10.1002/eji.200737072
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Bernhardt, Guenter
中科院分区：
文献类型：
--
作者：
Maier, Michael K.;Seth, Sebastian;Bernhardt, Guenter
CD155最初被称为脊髓灰质炎病毒的细胞受体，是免疫球蛋白样粘附受体亚家族的创始成员。除了其在接触上皮细胞之间建立粘附连接的功能外，CD 155与两种最近鉴定的配体CD 226和CD 96的接合介导免疫相关过程，例如NK细胞驱动的对人类肿瘤细胞的杀伤。在这里，我们报告的生成和免疫学分析的小鼠组成性缺乏的CD 155。此外，已经使用新建立的抗体确定了造血细胞上的CD 155的表达谱。CD 155缺陷型小鼠发育正常，不显示明显的表型。然而，这些动物的特点是在常规体液免疫应答的发展中存在明显的缺陷。而全身性的挑战显示没有差异，口服给药的抗原诱发效率较低的IgG和伊加抗体反应，尽管正常的IgM滴度相比，野生型小鼠。因此，CD155可能有助于在肠道免疫系统内产生有效的体液免疫应答。
CD155, originally known as the cellular receptor for poliovirus, is the founding member of a subfamily of immunoglobulin-like adhesion receptors. Apart from its function in establishing adherens junctions between contacting epithelial cells, the engagement of CD155 with two recently identified ligands, CD226 and CD96, mediates immunologically relevant processes such as NK cell-driven killing of tumor cells in humans. Here we report on the generation and immunological analysis of mice constitutively deficient of CD155. Moreover, the expression profile of CD155 on hematopoietic cells has been determined using newly established antibodies. CD 155-deficient mice develop normally without displaying an overt phenotype. However, the animals are distinguished by distinct deficits in the development of a regular humoral immune response. Whereas systemic challenges revealed no differences, orally administered antigen evoked less efficient IgG and IgA antibody responses despite of normal IgM titers when compared to wild-type mice. Therefore, CD155 may assist in an efficient humoral immune response generated within the intestinal immune system.