A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity
A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity
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DOI：
10.1590/s0103-50532009000700018
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发表时间：
2009-01-01
影响因子：
1.4
通讯作者：
Biavatti, Maique W.
中科院分区：
文献类型：
--
作者：
Buskuhl, Humberto;Freitas, Rilton A.;Biavatti, Maique W.
研究了从斑鸠菊科（菊科）叶和花的水醇粗提物中获得的二氯甲烷馏分，分离并阐明了一种新的聚乙炔，即 5-octa-2,4,6-triynyl-furan-2(5H)-one。根据 IR、NMR（1D 和 2D）和 MS 光谱数据确定了分离化合物的结构。研究了抗肿瘤潜力，包括对肿瘤细胞的细胞毒性和遗传毒性。结果表明，细胞凋亡可能至少部分是通过半胱天冬酶依赖性机制发生的。
The dichloromethane fraction obtained from hydroalcoholic crude extract of leaves and flowers of Vernonia scorpioides (Asteraceae) was investigated, resulting in the isolation and structure elucidation of a new polyacetylene namely 5-octa-2,4,6-triynyl-furan-2(5H)-one. The structure of the isolated compound was determined based on IR, NMR (1D and 2D) and MS spectrometric data. The antitumor potential, including cytotoxicity to tumor cells and genotoxicity, was investigated. The results suggest that apoptotic cell death may have occurred, at least in part, via a caspasedependent mechanism.