Retinoids: new insight into smooth muscle cell growth inhibition.
Retinoids: new insight into smooth muscle cell growth inhibition.
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类维生素A：对平滑肌细胞生长抑制的新见解。
DOI：
10.1161/01.atv.21.5.724
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Bradford C. Berk
中科院分区：
文献类型：
--
作者：
Joseph M. Miano;Bradford C. Berk
血管闭塞性疾病的成功治疗，特别是那些由于预先存在的动脉粥样硬化的程序性干预而导致的血管闭塞性疾病，可能需要靶向许多细胞过程，而不是任何一个基因、蛋白质或信号通路。几乎所有采用途径或因子特异性治疗来限制经皮血管介入后再狭窄的临床试验都失败了，这一事实得到了强调。类维生素A是维生素A的天然和合成衍生物，对细胞生长、凋亡、分化和迁移等过程产生无数影响。因此，类维生素a可能是血管闭塞性疾病的潜在治疗方法。在临床上，原型天然类维甲酸全反式维甲酸（atRA）对急性早幼粒细胞白血病患者的缓解率接近100%鉴于肿瘤和血管闭塞性病变的发病机制相似（即细胞生长增加和细胞分化特性丧失），令人惊讶的是，类维甲酸直到最近才被研究用于血管壁细胞。
The successful management of vascular occlusive diseases, particularly those due to procedural interventions for preexisting atherosclerosis, will likely require the targeting of numerous cellular processes rather than any 1 gene, protein, or signaling pathway. This fact is underscored by the failure of virtually all clinical trials employing pathway- or factor-specific therapeutics to limit restenosis after percutaneous vascular interventions. Retinoids are natural and synthetic derivatives of vitamin A that exert myriad effects on such cellular processes as growth, apoptosis, differentiation, and migration. As such, retinoids could be potential therapeutics to test in the context of vascular occlusive disease.1 2 3 4 Clinically, the prototypic natural retinoid, all- trans retinoic acid (atRA), effects a nearly 100% rate of remission in patients with acute promyelocytic leukemia.5 Given the similarities in the pathogenesis of neoplasia and vascular occlusive lesions (ie, increased cell growth and loss of cellular differentiated properties), it is surprising that retinoids have only recently been examined with respect to cells of the vascular wall.
Many retinoids exert their pleiotropic effects through the binding and activation of nuclear retinoid receptors. There are 2 families of retinoid receptors, each of which comprises 3 distinct genes. The retinoic acid receptors (RAR α, β, and γ) bind atRA and its 9- cis stereoisomer (9cRA), whereas the more weakly expressed retinoid X receptors (RXR α, β, and γ) bind 9cRA.6 Numerous retinoids have been synthesized and tested for receptor selectivity as a means of reducing the side effects associated with natural retinoid therapy. Many of these synthetic retinoids have recently found clinical utility for a number of diseases.4 Ligand-activated retinoid receptors dimerize (preferentially as an RAR-RXR heterodimer), recognize, and bind cis elements (called retinoic acid–response elements, or RAREs) in the genome to activate gene transcription. Identifying retinoid-responsive target genes is critical in …
类维生素A：血管平滑肌表型的多功能生物反应调节剂。
影响因子：
20.1
作者：
Miano,JM;Berk,BC
通讯作者：
Berk,BC
影响因子：
37.8
作者：
Miano, JM;Topouzis, S;Olson, EN
通讯作者：
Olson, EN
翻译后机制有助于人支气管上皮细胞中全反式视黄酸抑制特定的细胞周期蛋白：CDK 复合物。
DOI：
--
发表时间：
1999
期刊：
Cancer research.
影响因子：
--
作者：
Sueoka,N;Lee,HY;Walsh,GL;Hong,WK;Kurie,JM
通讯作者：
Kurie,JM