Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst
Synthesis of 3,5-disubstituted-1,2,4-oxadiazoles using tetrabutylammonium fluoride as a mild and efficient catalyst
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DOI：
10.1016/s0040-4039(00)02288-7
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发表时间：
2001-02-19
影响因子：
1.8
通讯作者：
Rice, KD
中科院分区：
文献类型：
--
作者：
Gangloff, AR;Litvak, J;Rice, KD
人们发现四丁基氟化铵 (TBAF) 是合成 3,5-二取代-1,2,4-恶二唑的温和且高效的催化剂。使用0.1-1.0当量的TBAF的THF溶液在室温下反应1-24小时，烷酰基-和芳酰基-脒以高收率转化为相应的3,5-二取代-1,2,4-恶二唑。研究了多种R和R'取代基。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Tetrabutylammonium fluoride (TBAF) was found to be a mild and efficient catalyst for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles. Using 0.1-1.0 equivalents of TBAF in THF for 1-24 h at room temperature, alkanoyl- and aroyl-oxyamidines were converted in high yield to the corresponding 3,5-disubstituted-l,2,4-oxadiazoles. A variety of R and R' substituents were investigated. (C) 2001 Elsevier Science Ltd. All rights reserved.