Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion.
Iron, zinc and copper in the Alzheimer's disease brain: a quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion.
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DOI：
10.1016/j.pneurobio.2011.05.001
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发表时间：
2011-08
影响因子：
6.7
通讯作者：
Kirsch, Wolff M.
中科院分区：
文献类型：
--
作者：
Schrag, Matthew;Mueller, Claudius;Oyoyo, Udochukwu;Smith, Mark A.;Kirsch, Wolff M.
过渡金属的稳态失调被认为在阿尔茨海默病（AD）的发病机制中起作用。虽然受到一些人的质疑，但脑铜、锌，特别是铁过载是AD的广泛接受的特征，这导致了以下假设：这些过渡金属的异常稳态产生的氧化应激可能是AD背后的致病机制。这项荟萃分析汇编并严格评估了AD患者与老年对照组相比脑铁、锌和铜水平的可用定量数据。结果非常不一致。来自一个实验室的一系列被大量引用的文章报道了与年龄匹配的对照组相比，AD新皮层中的铁大量增加（p<0.0001），而七个实验室未能重现这些发现，报告组间无显著差异（p=0.76）。发现超过三倍的引用偏倚有利于报告铁增加的离群值研究，这种偏倚在叙述性综述文章中尤为突出。此外，虽然锌在新皮层中没有显著变化（p=0.29），但铜在AD中显著耗尽（p=0.0003）。根据这些发现，重新评估过渡金属过载导致AD中的氧化损伤的假设将是重要的。
Dysfunctional homeostasis of transition metals is believed to play a role in the pathogenesis of Alzheimer’s disease (AD). Although questioned by some, brain copper, zinc, and particularly iron overload are widely accepted features of AD which have led to the hypothesis that oxidative stress generated from aberrant homeostasis of these transition metals might be a pathogenic mechanism behind AD. This meta-analysis compiled and critically assessed available quantitative data on brain iron, zinc and copper levels in AD patients compared to aged controls. The results were very heterogeneous. A series of heavily cited articles from one laboratory reported a large increase in iron in AD neocortex compared to age-matched controls (p<0.0001) while seven laboratories failed to reproduce these findings reporting no significant difference between the groups (p=0.76). A more than three-fold citation bias was found to favor outlier studies reporting increases in iron and this bias was particularly prominent among narrative review articles. Additionally, while zinc was not significantly changed in the neocortex (p=0.29), copper was significantly depleted in AD (p=0.0003). In light of these findings, it will be important to re-evaluate the hypothesis that transition metal overload accounts for oxidative injury noted in AD.
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影响因子：
3.7
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
5.5
作者：
Chavhan, Govind B.;Babyn, Paul S.;Haacke, E. Mark
通讯作者：
Haacke, E. Mark
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56.9
作者：
BUSH, AI;PETTINGELL, WH;TANZI, RE
通讯作者：
TANZI, RE
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作者：
Brunnstrom, Hans;Englund, Elisabet
通讯作者：
Englund, Elisabet
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作者：
Bax, Leon;Yu, Ly-Mee;Moons, Karel G. M.
通讯作者：
Moons, Karel G. M.