Frontal-striatal tract integrity and depression in older adults with and without multiple sclerosis.
Frontal-striatal tract integrity and depression in older adults with and without multiple sclerosis.
复制标题
DOI：
10.1007/s10072-024-07316-y
复制
发表时间：
2024-01
期刊：
影响因子：
--
通讯作者：
Sarah E Cote;M. Wagshul;Fredrick W Foley;Mary Anne Picone;Michael L Lipton;Jimmy S Lee;R. Holtzer
中科院分区：
文献类型：
--
作者：
Sarah E Cote;M. Wagshul;Fredrick W Foley;Mary Anne Picone;Michael L Lipton;Jimmy S Lee;R. Holtzer
额叶皮层下回路的较低白色物质完整性与正常衰老老年人的晚年抑郁症和多发性硬化症（MS）的存在有关。参与执行、认知、情感和运动功能的额纹状白色物质束可能是患有MS的老年人抑郁症的基础。本研究探讨了抑郁评分与老年人MS和对照组中额纹状白色物质完整性之间的相关性。方法患有MS的老年人（OAMS）（n= 67，平均年龄= 64.55 ± 3.89）和对照组（n= 74，平均年龄= 69.04 ± 6.32）进行脑MRI、认知评估、心理和运动测试。抑郁症通过30项老年抑郁量表进行评估。分数各向异性（FA）从两个双侧束提取：背外侧前额叶皮层到壳核（DLPFC-pn）和背外侧前额叶皮层到尾状核（DLPFC-cn）。抑郁症状（β= 0.357，p <0.001）。调整后的适度分析显示，通过FA相互作用，与对照组相比，OAMS中左侧DLPFC-pn束的FA与完全抑郁之间的关联显著更强（B=-61.70，p = .011）。条件效应显示，左侧DLPFC-pn的FA较低与更差（即，更高）抑郁症状（B=-38.0，p = .028）。其他三个道是不显着的适度models.ConclusionsWe提供了第一个证据，较低的白色物质完整性的左DLPFC-PN道与MS的老年人抑郁症更严重。
ObjectiveLower white matter integrity of frontal-subcortical circuitry has been associated with late-life depression in normally aging older adults and with the presence of multiple sclerosis (MS). Frontal-striatal white matter tracts involved in executive, cognitive, emotion, and motor function may underlie depression in older adults with MS. The present study examined the association between depression score and frontal-striatal white matter integrity in older adults with MS and controls.MethodsOlder adults with MS (OAMS) (n= 67, mean age = 64.55 ± 3.89) and controls (n= 74, mean age = 69.04 ± 6.32) underwent brain MRI, cognitive assessment, psychological, and motoric testing. Depression was assessed through the 30-item Geriatric Depression Scale. Fractional anisotropy (FA) was extracted from two bilateral tracts: dorsolateral prefrontal cortex to putamen nucleus (DLPFC-pn) and dorsolateral prefrontal cortex to caudate nucleus (DLPFC-cn).ResultsOAMS reported significantly worse (i.e., higher) depression symptoms (β= .357,p< .001) compared to healthy controls. Adjusted moderation analyses revealed, via group by FA interactions, significantly stronger associations between FA of the left DLPFC-pn tract and total depression (B= − 61.70,p= .011) among OAMS compared to controls. Conditional effects revealed that lower FA of the left DLPFC-pn was significantly associated with worse (i.e., higher) depression symptoms (b= − 38.0,p= .028) only among OAMS. The other three tracts were not significant in moderation models.ConclusionsWe provided first evidence that lower white matter integrity of the left DLPFC-pn tract was related to worse depression in older adults with MS.