The perinucleolar compartment associates with malignancy.
The perinucleolar compartment associates with malignancy.
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DOI：
10.1007/s11515-013-1265-z
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发表时间：
2013-08-01
期刊：
影响因子：
--
通讯作者：
Huang, Sui
中科院分区：
文献类型：
--
作者：
Wen, Yiping;Wang, Chen;Huang, Sui
The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.
