Suppression of adult copulatory behaviors following LiCl-induced aversive contingencies in juvenile male rats.
Suppression of adult copulatory behaviors following LiCl-induced aversive contingencies in juvenile male rats.
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DOI：
10.1002/dev.420200606
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发表时间：
1987-11
影响因子：
2.2
通讯作者：
P. C. Koch;R. H. Peters
中科院分区：
文献类型：
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作者：
P. C. Koch;R. H. Peters
性不成熟的幼年雄性大鼠在与发情期雌性大鼠配对8-10次（间隔2-3天）期间接受0.3 M（20 ml/kg）氯化锂（LiCl）注射。大约7周后，这些雄性大鼠与发情雌性大鼠配对时的交配行为比生理盐水对照组大鼠少。非偶然的.3 M氯化锂注射给青少年男性没有影响成年交配行为。在保留时间间隔内分组或单独圈养的雄性动物显示出相当的抑制，这表明交配抑制并不代表对与另一只动物进行社会互动的普遍厌恶。在保留间隔期间，在含有发情期雌性气味的环境中圈养的雄性也显示出与在没有这种气味的情况下圈养的雄性相当的抑制。这表明介导交配抑制的关联并不仅仅是由发情雌性的气味线索引起的。这些数据表明，氯化锂引起的厌恶意外事件在少年雄性大鼠随后抑制成年交配行为。
Sexually immature juvenile male rats received an injection of .3 M (20 ml/kg) lithium chloride (LiCl) during each of 8-10 pairings (spaced at 2-3-day intervals) with an estrous female. Approximately seven weeks later, these males displayed fewer copulatory behaviors in pairings with estrous females than saline control rats. Noncontingent .3 M LiCl injections administered to juvenile males did not affect adult copulatory behaviors. Males that were either group or individually housed during the retention interval displayed comparable suppression, which suggests that copulatory suppression does not represent a generalized aversion to social interactions with another animal. Males housed during the retention interval in an environment that contained the odors of estrous females also displayed suppression comparable to that of males housed in the absence of such odors. This suggests that the associations that mediate copulatory suppression are not elicited solely by the odor cues of estrous females. These data demonstrate that LiCl-induced aversive contingencies in juvenile male rats subsequently suppress adult copulatory behaviors.