Value of new contrast harmonic technique for detecting tumor vascularity in hepatocellular carcinoma: Preliminary results
Value of new contrast harmonic technique for detecting tumor vascularity in hepatocellular carcinoma: Preliminary results
复制标题
新对比谐波技术检测肝细胞癌肿瘤血管分布的价值：初步结果
DOI：
10.1007/bf02481368
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发表时间：
2003
影响因子：
1.8
通讯作者：
K. Maekawa
中科院分区：
文献类型：
--
作者：
Y. Wen;M. Kudo;Y. Minami;Hobyung Chung;Y. Suetomi;H. Onda;M. Kitano;T. Kawasaki;K. Maekawa
目的：探讨一种新的宽带对比谐波成像方法在描述肝癌肿瘤内血管的价值。材料和方法：22例患者28个肝癌结节，采用对比谐波回波，一种新的宽带谐波成像方法，使用Levovist®作为对比增强剂。在早期动脉期进行间歇成像10至40秒，在晚期血管期进行间歇成像1至2分钟，在血管后期进行间歇成像5至7分钟。减影图像在晚期血管相使用多激发方法获得。对比谐波回波成像检测肝细胞癌血管的能力进行了比较，通过analzing使用动态CT作为一个金标准，结果：对比谐波回波成像检测肿瘤内的血管，肿瘤实质染色，灌注缺损，在早期动脉相，晚期血管相，和血管后相，分别。在晚期血管相，减影图像清楚地描绘了肿瘤实质应变。谐波超声造影在25个（89%）肝细胞癌结节中检测到瘤内血管，而彩色多普勒成像仅15个（54%）（p<0.05）。结论：谐波声学造影在显示肿瘤内血管和实质染色方面优于彩色多普勒成像，与动态CT三期扫描结果一致，具有上级优势。
Purpose: To investigate the value of a new wide-band contrast harmonic imaging method in depicting intratumoral vascularity in hepatocellular carcinoma.Materials and Methods: Twenty-two patients with 28 hepatocellular carcinoma nodules evaluated with Contrast Harmonic Echo, a new wide-band harmonic imaging method, using Levovist®as a contrast-enhancing agent. Intermittent imaging was carried out in the early arterial phase for 10 to 40 seconds, in the late vascular phase for 1 to 2 minutes, and in the postvascular phase for 5 to 7 minutes. Subtraction images were obtained using the multishot method during the late vascular phase. The ability of Contrast Harmonic Echo imaging to detect vascularity in hepatocellular carcinoma was compared to that of unenhanced color Doppler imaging by analzing results obtained using dynamic CT as a gold standard.Results: Contrast harmonic Echo imaging detected intratumoral vessels, tumor parenchymal stain, and perfusion defect in the early arterial phase, the late vascular phase, and the postvascular phase, respectively. In the late vascular phase, the subtraction image clearly delineated the tumor parenchymal strain. Intratumoral vascularity was detected in 25 (89%) of the hepatocellular carcinoma nodules by Contrast Harmonic Echo, compared with 15 (54%) when color Doppler imaging was used (p<0.05). The diagnostic sensitivity, specificity, and accuracy of Contrast Harmonic Echo were 96.1%, 100% and 96.4%, respectively, corresponding to results obtained using dynamic CT.Conclusion: Contrast Harmonic Echo imaging is superior to unenhanced color Doppler imaging in depicting intratumoral vessels and parenchymal stain, and agrees closely with results obtained with three-phase dynamic CT.