Does the difference between physically active and couch potato lie in the dopamine system?
Does the difference between physically active and couch potato lie in the dopamine system?
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DOI：
10.7150/ijbs.6.133
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发表时间：
2010-03-09
影响因子：
9.2
通讯作者：
Lightfoot JT
中科院分区：
文献类型：
--
作者：
Knab AM;Lightfoot JT
肥胖和其他与不活动有关的疾病正在以惊人的速度增加，特别是在西方社会。正因为如此，了解身体活动行为的调节机制是很重要的。关于身体活动行为的心理决定因素已经做了很多研究；然而，关于可能有助于调节这一复杂特征的潜在的遗传和生物因素，人们知之甚少。诚然，任何性状的很大一部分都是由遗传和生物因素决定的。在自愿身体活动行为的情况下，这些调节机制似乎集中在中枢神经系统。具体地说，多巴胺系统已被证明可以调节运动，以及动机和奖励行为。多巴胺系统对自愿体力活动的调节模式尚未完全阐明。这篇综述将总结有关多巴胺系统和体力活动调节的已知情况，并提出一个假说，说明这一信号通路如何机械地参与调节自愿体力活动行为。未来在这一领域的研究将有助于制定个性化的策略，以预防与不活动相关的疾病。
Obesity and other inactivity related diseases are increasing at an alarming rate especially in Western societies. Because of this, it is important to understand the regulating mechanisms involved in physical activity behavior. Much research has been done in regard to the psychological determinants of physical activity behavior; however, little is known about the underlying genetic and biological factors that may contribute to regulation of this complex trait. It is true that a significant portion of any trait is regulated by genetic and biological factors. In the case of voluntary physical activity behavior, these regulating mechanisms appear to be concentrated in the central nervous system. In particular, the dopamine system has been shown to regulate motor movement, as well as motivation and reward behavior. The pattern of regulation of voluntary physical activity by the dopamine system is yet to be fully elucidated. This review will summarize what is known about the dopamine system and regulation of physical activity, and will present a hypothesis of how this signaling pathway is mechanistically involved in regulating voluntary physical activity behavior. Future research in this area will aid in developing personalized strategies to prevent inactivity related diseases.