Impact of sex and gender on irritable bowel syndrome.
Impact of sex and gender on irritable bowel syndrome.
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DOI：
10.1177/1099800403005001006
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发表时间：
2003-07-01
影响因子：
2.5
通讯作者：
Chang, Lin
中科院分区：
文献类型：
--
作者：
Heitkemper, Margaret;Jarrett, Monica;Chang, Lin
肠易激综合征（IBS）是一种常见的功能性肠道疾病，其特征是腹痛和排便方式改变。这篇综述讨论了患有和不患有肠易激综合症的个体可能存在的性别（遗传、生物学）和性别（经验、知觉）差异的主题。一些观察使该主题变得重要。首先，在美国和其他工业化社会，寻求 IBS 医疗保健服务的女性比例高于男性。其次，IBS 症状报告中观察到与月经周期相关的差异。第三，患有肠易激综合症的女性往往会报告更大的便秘问题以及与肠易激综合症相关的非胃肠道疾病。第四，与男性相比，血清素 (5-HT3) 受体拮抗剂和 5-HT4 部分激动剂药物似乎可以更有效地减少 IBS 女性肠道模式紊乱的报道。这篇综述探讨了胃肠道运动和运输的性别和性别调节、内脏疼痛敏感性、自主神经系统功能、血清素生化以及 IBS 就医行为的差异。
Irritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and change in defecation pattern. This review addresses the topic of possible sex (genetic, biological) and gender (experiential, perceptual) differences in individuals with and without IBS. Several observations make the topic important. First, there is a predominance of women as compared to men who seek health care services for IBS in the United States and other industrialized societies. Second, menstrual cycle-linked differences are observed in IBS symptom reports. Third, women with IBS tend to report greater problems with constipation and nongastrointestinal complaints associated with IBS. Fourth, serotonin (5-HT3) receptor antagonist and 5-HT4 partial agonist drugs appear to more effectively diminish reports of bowel pattern disruption in women with IBS as compared to men. This review examines sex and gender modulation of gastrointestinal motility and transit, visceral pain sensitivity, autonomic nervous system function, serotonin biochemistry, and differences in health care-seeking behavior for IBS.